000 01488 a2200445 4500
005 20250516214152.0
264 0 _c20150207
008 201502s 0 0 eng d
022 _a1365-2125
024 7 _a10.1111/bcp.12256
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGueorguieva, Ivelina
245 0 0 _aDefining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model.
_h[electronic resource]
260 _bBritish journal of clinical pharmacology
_cMay 2014
300 _a796-807 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAdult
650 0 4 _aAged
650 0 4 _aBiomarkers
650 0 4 _aCohort Studies
650 0 4 _aDrug Discovery
650 0 4 _aFemale
650 0 4 _aGlioblastoma
_xdrug therapy
650 0 4 _aHumans
650 0 4 _aMale
650 0 4 _aMiddle Aged
650 0 4 _aModels, Biological
650 0 4 _aPyrazoles
_xpharmacokinetics
650 0 4 _aQuinolines
_xpharmacokinetics
650 0 4 _aTransforming Growth Factor beta
_xantagonists & inhibitors
700 1 _aCleverly, Ann L
700 1 _aStauber, Anja
700 1 _aSada Pillay, N
700 1 _aRodon, Jordi A
700 1 _aMiles, Colin P
700 1 _aYingling, Jonathan M
700 1 _aLahn, Michael M
773 0 _tBritish journal of clinical pharmacology
_gvol. 77
_gno. 5
_gp. 796-807
856 4 0 _uhttps://doi.org/10.1111/bcp.12256
_zAvailable from publisher's website
999 _c23862770
_d23862770