000 01459 a2200397 4500
005 20250516203116.0
264 0 _c20140706
008 201407s 0 0 eng d
022 _a1538-7445
024 7 _a10.1158/0008-5472.CAN-13-2482
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aOffer, Steven M
245 0 0 _aComparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity.
_h[electronic resource]
260 _bCancer research
_cMay 2014
300 _a2545-54 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAmino Acid Sequence
650 0 4 _aAntimetabolites, Antineoplastic
_xchemistry
650 0 4 _aBiotransformation
650 0 4 _aDihydrouracil Dehydrogenase (NADP)
_xbiosynthesis
650 0 4 _aEnzyme Assays
650 0 4 _aFluorouracil
_xchemistry
650 0 4 _aGene Frequency
650 0 4 _aGenetic Association Studies
650 0 4 _aHEK293 Cells
650 0 4 _aHumans
650 0 4 _aMolecular Sequence Data
650 0 4 _aMutation, Missense
700 1 _aFossum, Croix C
700 1 _aWegner, Natalie J
700 1 _aStuflesser, Alexander J
700 1 _aButterfield, Gabriel L
700 1 _aDiasio, Robert B
773 0 _tCancer research
_gvol. 74
_gno. 9
_gp. 2545-54
856 4 0 _uhttps://doi.org/10.1158/0008-5472.CAN-13-2482
_zAvailable from publisher's website
999 _c23657475
_d23657475