000 01970 a2200541 4500
005 20250516200641.0
264 0 _c20140703
008 201407s 0 0 eng d
022 _a1532-6535
024 7 _a10.1038/clpt.2014.50
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSager, J E
245 0 0 _aFluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
_h[electronic resource]
260 _bClinical pharmacology and therapeutics
_cJun 2014
300 _a653-62 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAdult
650 0 4 _aAntidepressive Agents, Second-Generation
_xadministration & dosage
650 0 4 _aArea Under Curve
650 0 4 _aAryl Hydrocarbon Hydroxylases
_xantagonists & inhibitors
650 0 4 _aBiotransformation
650 0 4 _aComputer Simulation
650 0 4 _aCytochrome P-450 CYP2C19
650 0 4 _aCytochrome P-450 CYP2D6
_xmetabolism
650 0 4 _aCytochrome P-450 CYP2D6 Inhibitors
650 0 4 _aCytochrome P-450 CYP3A
_xmetabolism
650 0 4 _aCytochrome P-450 CYP3A Inhibitors
650 0 4 _aDextromethorphan
_xpharmacokinetics
650 0 4 _aDrug Interactions
650 0 4 _aFemale
650 0 4 _aFluoxetine
_xadministration & dosage
650 0 4 _aHalf-Life
650 0 4 _aHepatocytes
_xdrug effects
650 0 4 _aHumans
650 0 4 _aLovastatin
_xpharmacokinetics
650 0 4 _aMale
650 0 4 _aMidazolam
_xpharmacokinetics
650 0 4 _aModels, Statistical
650 0 4 _aOmeprazole
_xpharmacokinetics
650 0 4 _aStereoisomerism
700 1 _aLutz, J D
700 1 _aFoti, R S
700 1 _aDavis, C
700 1 _aKunze, K L
700 1 _aIsoherranen, N
773 0 _tClinical pharmacology and therapeutics
_gvol. 95
_gno. 6
_gp. 653-62
856 4 0 _uhttps://doi.org/10.1038/clpt.2014.50
_zAvailable from publisher's website
999 _c23585789
_d23585789