000			02256 a2200613 4500
005			20250516192034.0
264		0	_c20140220
008			201402s 0 0 eng d
022			_a2213-2600
024	7		_a10.1016/S2213-2600(13)70187-5 _2doi
040			_aNLM _beng _cNLM
100	1		_aFranciosi, Lui G
245	0	0	_aEfficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. _h[electronic resource]
260			_bThe Lancet. Respiratory medicine _cNov 2013
300			_a714-27 p. _bdigital
500			_aPublication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Inhalation
650	0	4	_aAdult
650	0	4	_aAged
650	0	4	_aAsthma _xdrug therapy
650	0	4	_aFemale
650	0	4	_aFollow-Up Studies
650	0	4	_aForced Expiratory Volume _xdrug effects
650	0	4	_aHealthy Volunteers
650	0	4	_aHumans
650	0	4	_aIsoquinolines _xadministration & dosage
650	0	4	_aMale
650	0	4	_aMiddle Aged
650	0	4	_aNebulizers and Vaporizers
650	0	4	_aPhosphodiesterase 3 Inhibitors _xadministration & dosage
650	0	4	_aPhosphodiesterase 4 Inhibitors _xadministration & dosage
650	0	4	_aProspective Studies
650	0	4	_aPulmonary Disease, Chronic Obstructive _xdrug therapy
650	0	4	_aPyrimidinones _xadministration & dosage
650	0	4	_aSingle-Blind Method
650	0	4	_aTreatment Outcome
650	0	4	_aYoung Adult
700	1		_aDiamant, Zuzana
700	1		_aBanner, Katharine H
700	1		_aZuiker, Rob
700	1		_aMorelli, Nicoletta
700	1		_aKamerling, Ingrid M C
700	1		_ade Kam, Marieke L
700	1		_aBurggraaf, Jacobus
700	1		_aCohen, Adam F
700	1		_aCazzola, Mario
700	1		_aCalzetta, Luigino
700	1		_aSingh, Dave
700	1		_aSpina, Domenico
700	1		_aWalker, Michael J A
700	1		_aPage, Clive P
773	0		_tThe Lancet. Respiratory medicine _gvol. 1 _gno. 9 _gp. 714-27
856	4	0	_uhttps://doi.org/10.1016/S2213-2600(13)70187-5 _zAvailable from publisher's website
999			_c23453488 _d23453488