000 01905 a2200517 4500
005 20250516180835.0
264 0 _c20140919
008 201409s 0 0 eng d
022 _a1768-3254
024 7 _a10.1016/j.ejmech.2013.10.038
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKovács, Dóra
245 0 0 _aAn efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.
_h[electronic resource]
260 _bEuropean journal of medicinal chemistry
_c2013
300 _a649-60 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAndrostenes
_xchemical synthesis
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCyclization
650 0 4 _aDehydration
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aEnzyme Inhibitors
_xchemical synthesis
650 0 4 _aHeLa Cells
650 0 4 _aHumans
650 0 4 _aMCF-7 Cells
650 0 4 _aMale
650 0 4 _aMolecular Conformation
650 0 4 _aOximes
_xchemistry
650 0 4 _aRats
650 0 4 _aRats, Wistar
650 0 4 _aSteroid 17-alpha-Hydroxylase
_xantagonists & inhibitors
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTestis
_xenzymology
700 1 _aWölfling, János
700 1 _aSzabó, Nikoletta
700 1 _aSzécsi, Mihály
700 1 _aKovács, Ida
700 1 _aZupkó, István
700 1 _aFrank, Eva
773 0 _tEuropean journal of medicinal chemistry
_gvol. 70
_gp. 649-60
856 4 0 _uhttps://doi.org/10.1016/j.ejmech.2013.10.038
_zAvailable from publisher's website
999 _c23247951
_d23247951