| 000 | 02395 a2200661 4500 | ||
|---|---|---|---|
| 005 | 20250516171426.0 | ||
| 264 | 0 | _c20140310 | |
| 008 | 201403s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm401094t _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aGoodfellow, Val S | |
| 245 | 0 | 0 |
_aDiscovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cOct 2013 |
||
| 300 |
_a8032-48 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAdministration, Oral |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aArea Under Curve |
| 650 | 0 | 4 | _aBiological Availability |
| 650 | 0 | 4 |
_aBlood-Brain Barrier _xmetabolism |
| 650 | 0 | 4 |
_aBrain _xmetabolism |
| 650 | 0 | 4 |
_aCarbazoles _xchemical synthesis |
| 650 | 0 | 4 | _aCells, Cultured |
| 650 | 0 | 4 |
_aCognition Disorders _xcomplications |
| 650 | 0 | 4 |
_aDrug Discovery _xmethods |
| 650 | 0 | 4 |
_aHIV Infections _xcomplications |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aJNK Mitogen-Activated Protein Kinases _xmetabolism |
| 650 | 0 | 4 |
_aMAP Kinase Kinase Kinases _xantagonists & inhibitors |
| 650 | 0 | 4 | _aMale |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMice, Inbred C57BL |
| 650 | 0 | 4 | _aModels, Chemical |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 |
_aMonocytes _xdrug effects |
| 650 | 0 | 4 |
_aPhosphorylation _xdrug effects |
| 650 | 0 | 4 |
_aProtein Kinase Inhibitors _xchemical synthesis |
| 650 | 0 | 4 |
_aPyridines _xchemical synthesis |
| 650 | 0 | 4 |
_aPyrroles _xchemical synthesis |
| 650 | 0 | 4 |
_aTumor Necrosis Factor-alpha _xmetabolism |
| 650 | 0 | 4 |
_atat Gene Products, Human Immunodeficiency Virus _xpharmacology |
| 650 | 0 | 4 | _aMitogen-Activated Protein Kinase Kinase Kinase 11 |
| 700 | 1 | _aLoweth, Colin J | |
| 700 | 1 | _aRavula, Satheesh B | |
| 700 | 1 | _aWiemann, Torsten | |
| 700 | 1 | _aNguyen, Thong | |
| 700 | 1 | _aXu, Yang | |
| 700 | 1 | _aTodd, Daniel E | |
| 700 | 1 | _aSheppard, David | |
| 700 | 1 | _aPollack, Scott | |
| 700 | 1 | _aPolesskaya, Oksana | |
| 700 | 1 | _aMarker, Daniel F | |
| 700 | 1 | _aDewhurst, Stephen | |
| 700 | 1 | _aGelbard, Harris A | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 56 _gno. 20 _gp. 8032-48 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm401094t _zAvailable from publisher's website |
| 999 |
_c23096741 _d23096741 |
||