000 01674 a2200469 4500
005 20250516163427.0
264 0 _c20130910
008 201309s 0 0 eng d
022 _a0001-6837
040 _aNLM
_beng
_cNLM
100 1 _aAmin, Kamelia M
245 0 0 _aA novel class of substituted spiro [quinazoline-2,1'-cyclohexane] derivatives as effective PPAR-1 inhibitors: molecular modeling, synthesis, cytotoxic and enzyme assay evaluation.
_h[electronic resource]
260 _bActa poloniae pharmaceutica
_c
300 _a687-708 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aBenzamides
_xpharmacology
650 0 4 _aBinding Sites
650 0 4 _aBreast Neoplasms
_xenzymology
650 0 4 _aCell Proliferation
650 0 4 _aComputer-Aided Design
650 0 4 _aCyclohexanes
_xchemical synthesis
650 0 4 _aDoxorubicin
_xpharmacology
650 0 4 _aDrug Design
650 0 4 _aEnzyme Inhibitors
_xchemical synthesis
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aMCF-7 Cells
650 0 4 _aMolecular Docking Simulation
650 0 4 _aPoly (ADP-Ribose) Polymerase-1
650 0 4 _aPoly(ADP-ribose) Polymerase Inhibitors
650 0 4 _aPoly(ADP-ribose) Polymerases
_xchemistry
650 0 4 _aProtein Conformation
650 0 4 _aQuinazolines
_xchemical synthesis
700 1 _aAnwar, Manal M
700 1 _aSyam, Yasmin M
700 1 _aKhedr, Mohammed A
700 1 _aKhedr, Mohammed
700 1 _aKamel, Mohsen M
700 1 _aKassem, Emad M M
773 0 _tActa poloniae pharmaceutica
_gvol. 70
_gno. 4
_gp. 687-708
999 _c22983318
_d22983318