000 02155 a2200577 4500
005 20250516163231.0
264 0 _c20131212
008 201312s 0 0 eng d
022 _a1538-7445
024 7 _a10.1158/0008-5472.CAN-13-1191
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGarrett, Joan T
245 0 0 _aCombination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers.
_h[electronic resource]
260 _bCancer research
_cOct 2013
300 _a6013-23 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAntibodies, Monoclonal, Humanized
_xpharmacology
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aBreast Neoplasms
_xmetabolism
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aClass I Phosphatidylinositol 3-Kinases
_xantagonists & inhibitors
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aImmunoblotting
650 0 4 _aImmunoprecipitation
650 0 4 _aLapatinib
650 0 4 _aMice
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aProtein Multimerization
_xdrug effects
650 0 4 _aProto-Oncogene Proteins c-akt
_xantagonists & inhibitors
650 0 4 _aQuinazolines
_xpharmacology
650 0 4 _aReceptor, ErbB-2
_xantagonists & inhibitors
650 0 4 _aReceptor, ErbB-3
_xantagonists & inhibitors
650 0 4 _aSignal Transduction
650 0 4 _aSurvival Rate
650 0 4 _aTrastuzumab
650 0 4 _aTumor Cells, Cultured
650 0 4 _aXenograft Model Antitumor Assays
700 1 _aSutton, Cammie R
700 1 _aKurupi, Richard
700 1 _aBialucha, Carl Uli
700 1 _aEttenberg, Seth A
700 1 _aCollins, Scott D
700 1 _aSheng, Qing
700 1 _aWallweber, Jerry
700 1 _aDefazio-Eli, Lisa
700 1 _aArteaga, Carlos L
773 0 _tCancer research
_gvol. 73
_gno. 19
_gp. 6013-23
856 4 0 _uhttps://doi.org/10.1158/0008-5472.CAN-13-1191
_zAvailable from publisher's website
999 _c22979003
_d22979003