000 02005 a2200553 4500
005 20250516160641.0
264 0 _c20140205
008 201402s 0 0 eng d
022 _a1932-6203
024 7 _a10.1371/journal.pone.0066388
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSceneay, Jaclyn
245 0 0 _aThe antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
_h[electronic resource]
260 _bPloS one
_c2013
300 _ae66388 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAcetylcysteine
_xpharmacology
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aAntioxidants
_xpharmacology
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCarcinogenesis
650 0 4 _aCell Hypoxia
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aEpithelial-Mesenchymal Transition
650 0 4 _aFemale
650 0 4 _aGlutathione
_xblood
650 0 4 _aHypoxia-Inducible Factor 1, alpha Subunit
_xmetabolism
650 0 4 _aLung Neoplasms
_xblood supply
650 0 4 _aMammary Neoplasms, Experimental
_xblood supply
650 0 4 _aMice
650 0 4 _aMice, Inbred BALB C
650 0 4 _aMice, Inbred C57BL
650 0 4 _aNeoplasm Transplantation
650 0 4 _aNeovascularization, Pathologic
_xmetabolism
650 0 4 _aPhenotype
650 0 4 _aProtein Stability
650 0 4 _aTumor Burden
_xdrug effects
650 0 4 _aVascular Endothelial Growth Factor A
_xmetabolism
700 1 _aLiu, Mira C P
700 1 _aChen, Anna
700 1 _aWong, Christina S F
700 1 _aBowtell, David D L
700 1 _aMöller, Andreas
773 0 _tPloS one
_gvol. 8
_gno. 6
_gp. e66388
856 4 0 _uhttps://doi.org/10.1371/journal.pone.0066388
_zAvailable from publisher's website
999 _c22904827
_d22904827