000			01904 a2200529 4500
005			20250516155701.0
264		0	_c20140213
008			201402s 0 0 eng d
022			_a1546-1696
024	7		_a10.1038/nbt.2620 _2doi
040			_aNLM _beng _cNLM
100	1		_aTaipale, Mikko
245	0	0	_aChaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. _h[electronic resource]
260			_bNature biotechnology _cJul 2013
300			_a630-7 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650	0	4	_aAnimals
650	0	4	_aCell Cycle Proteins _xgenetics
650	0	4	_aCrizotinib
650	0	4	_aDrug Approval
650	0	4	_aDrug Interactions
650	0	4	_aHSP90 Heat-Shock Proteins _xmetabolism
650	0	4	_aHumans
650	0	4	_aMice
650	0	4	_aMolecular Chaperones _xmetabolism
650	0	4	_aNeoplasms _xdrug therapy
650	0	4	_aPhosphotransferases _xantagonists & inhibitors
650	0	4	_aProtein Binding
650	0	4	_aProtein Kinase Inhibitors _xtherapeutic use
650	0	4	_aProto-Oncogene Proteins c-ets _xmetabolism
650	0	4	_aPyrazoles _xtherapeutic use
650	0	4	_aPyridines _xtherapeutic use
650	0	4	_aReceptor, trkC _xmetabolism
650	0	4	_aRepressor Proteins _xmetabolism
650	0	4	_aSubstrate Specificity
650	0	4	_aXenograft Model Antitumor Assays
650	0	4	_aETS Translocation Variant 6 Protein
700	1		_aKrykbaeva, Irina
700	1		_aWhitesell, Luke
700	1		_aSantagata, Sandro
700	1		_aZhang, Jianming
700	1		_aLiu, Qingsong
700	1		_aGray, Nathanael S
700	1		_aLindquist, Susan
773	0		_tNature biotechnology _gvol. 31 _gno. 7 _gp. 630-7
856	4	0	_uhttps://doi.org/10.1038/nbt.2620 _zAvailable from publisher's website
999			_c22877144 _d22877144