000 01831 a2200493 4500
005 20250516150635.0
264 0 _c20140123
008 201401s 0 0 eng d
022 _a1860-7187
024 7 _a10.1002/cmdc.201300112
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aEhmke, Veronika
245 0 0 _aOptimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.
_h[electronic resource]
260 _bChemMedChem
_cJun 2013
300 _a967-75 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aCathepsin L
_xchemistry
650 0 4 _aCrystallography, X-Ray
650 0 4 _aCysteine Endopeptidases
_xmetabolism
650 0 4 _aCysteine Proteinase Inhibitors
_xchemical synthesis
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aHumans
650 0 4 _aImidazoles
_xchemical synthesis
650 0 4 _aLigands
650 0 4 _aModels, Molecular
650 0 4 _aMolecular Structure
650 0 4 _aNitriles
_xchemical synthesis
650 0 4 _aParasitic Sensitivity Tests
650 0 4 _aPyridines
_xchemical synthesis
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTriazines
_xchemical synthesis
650 0 4 _aTrypanosoma brucei brucei
_xdrug effects
700 1 _aWinkler, Edwin
700 1 _aBanner, David W
700 1 _aHaap, Wolfgang
700 1 _aSchweizer, W Bernd
700 1 _aRottmann, Matthias
700 1 _aKaiser, Marcel
700 1 _aFreymond, Céline
700 1 _aSchirmeister, Tanja
700 1 _aDiederich, François
773 0 _tChemMedChem
_gvol. 8
_gno. 6
_gp. 967-75
856 4 0 _uhttps://doi.org/10.1002/cmdc.201300112
_zAvailable from publisher's website
999 _c22735991
_d22735991