000 01759 a2200457 4500
005 20250516142939.0
264 0 _c20131022
008 201310s 0 0 eng d
022 _a1347-5223
024 7 _a10.1248/cpb.c12-00993
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aAbadi, Ashraf Hassan
245 0 0 _aModulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.
_h[electronic resource]
260 _bChemical & pharmaceutical bulletin
_c2013
300 _a405-10 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aBinding Sites
650 0 4 _aCatalytic Domain
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCyclic GMP
_xmetabolism
650 0 4 _aCyclic Nucleotide Phosphodiesterases, Type 3
_xchemistry
650 0 4 _aCyclization
650 0 4 _aHT29 Cells
650 0 4 _aHumans
650 0 4 _aHydrolysis
650 0 4 _aMolecular Docking Simulation
650 0 4 _aPhosphodiesterase 3 Inhibitors
_xchemistry
650 0 4 _aProtein Binding
650 0 4 _aPyridines
_xchemistry
650 0 4 _aPyrimidines
_xchemistry
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSubstrate Specificity
700 1 _aHany, Marwa Saeed
700 1 _aElsharif, Shimaa Awadain
700 1 _aEissa, Amal Abdel Haleem
700 1 _aGary, Bernard Dewayne
700 1 _aTinsley, Heather Nicole
700 1 _aPiazza, Gary Anthony
773 0 _tChemical & pharmaceutical bulletin
_gvol. 61
_gno. 4
_gp. 405-10
856 4 0 _uhttps://doi.org/10.1248/cpb.c12-00993
_zAvailable from publisher's website
999 _c22631063
_d22631063