000 02541 a2200793 4500
005 20250516140501.0
264 0 _c20130314
008 201303s 0 0 eng d
022 _a1095-9203
024 7 _a10.1126/science.1231097
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHubbard, Basil P
245 0 0 _aEvidence for a common mechanism of SIRT1 regulation by allosteric activators.
_h[electronic resource]
260 _bScience (New York, N.Y.)
_cMar 2013
300 _a1216-9 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
650 0 4 _aAllosteric Regulation
650 0 4 _aAmino Acid Motifs
650 0 4 _aAmino Acid Sequence
650 0 4 _aAmino Acid Substitution
650 0 4 _aAnimals
650 0 4 _aCells, Cultured
650 0 4 _aEnzyme Activation
650 0 4 _aForkhead Box Protein O3
650 0 4 _aForkhead Transcription Factors
_xchemistry
650 0 4 _aGlutamic Acid
_xchemistry
650 0 4 _aHeterocyclic Compounds, 4 or More Rings
_xchemistry
650 0 4 _aHumans
650 0 4 _aHydrophobic and Hydrophilic Interactions
650 0 4 _aMice
650 0 4 _aMolecular Sequence Data
650 0 4 _aMyoblasts
_xdrug effects
650 0 4 _aProtein Structure, Tertiary
650 0 4 _aResveratrol
650 0 4 _aSirtuin 1
_xchemistry
650 0 4 _aStilbenes
_xchemistry
650 0 4 _aSubstrate Specificity
700 1 _aGomes, Ana P
700 1 _aDai, Han
700 1 _aLi, Jun
700 1 _aCase, April W
700 1 _aConsidine, Thomas
700 1 _aRiera, Thomas V
700 1 _aLee, Jessica E
700 1 _aE, Sook Yen
700 1 _aLamming, Dudley W
700 1 _aPentelute, Bradley L
700 1 _aSchuman, Eli R
700 1 _aStevens, Linda A
700 1 _aLing, Alvin J Y
700 1 _aArmour, Sean M
700 1 _aMichan, Shaday
700 1 _aZhao, Huizhen
700 1 _aJiang, Yong
700 1 _aSweitzer, Sharon M
700 1 _aBlum, Charles A
700 1 _aDisch, Jeremy S
700 1 _aNg, Pui Yee
700 1 _aHowitz, Konrad T
700 1 _aRolo, Anabela P
700 1 _aHamuro, Yoshitomo
700 1 _aMoss, Joel
700 1 _aPerni, Robert B
700 1 _aEllis, James L
700 1 _aVlasuk, George P
700 1 _aSinclair, David A
773 0 _tScience (New York, N.Y.)
_gvol. 339
_gno. 6124
_gp. 1216-9
856 4 0 _uhttps://doi.org/10.1126/science.1231097
_zAvailable from publisher's website
999 _c22563524
_d22563524