000			01968 a2200505 4500
005			20250516130917.0
264		0	_c20131104
008			201311s 0 0 eng d
022			_a1521-009X
024	7		_a10.1124/dmd.112.048488 _2doi
040			_aNLM _beng _cNLM
100	1		_aZamek-Gliszczynski, Maciej J
245	0	0	_aPharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure. _h[electronic resource]
260			_bDrug metabolism and disposition: the biological fate of chemicals _cApr 2013
300			_a714-26 p. _bdigital
500			_aPublication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xmetabolism
650	0	4	_aBile _xmetabolism
650	0	4	_aDogs
650	0	4	_aFeces _xchemistry
650	0	4	_aGlycogen Synthase Kinase 3 _xantagonists & inhibitors
650	0	4	_aGlycogen Synthase Kinase 3 beta
650	0	4	_aHeterocyclic Compounds, 3-Ring _xpharmacokinetics
650	0	4	_aHumans
650	0	4	_aMale
650	0	4	_aMaleimides _xpharmacokinetics
650	0	4	_aMicrosomes, Liver _xmetabolism
650	0	4	_aProtein Kinase Inhibitors _xmetabolism
650	0	4	_aRats
650	0	4	_aUrine _xchemistry
700	1		_aAbraham, Trent L
700	1		_aAlberts, Jeffrey J
700	1		_aKulanthaivel, Palaniappan
700	1		_aJackson, Kimberley A
700	1		_aChow, Kay H
700	1		_aMcCann, Denis J
700	1		_aHu, Haitao
700	1		_aAnderson, Shelby
700	1		_aFurr, Nathan A
700	1		_aBarbuch, Robert J
700	1		_aCassidy, Kenneth C
773	0		_tDrug metabolism and disposition: the biological fate of chemicals _gvol. 41 _gno. 4 _gp. 714-26
856	4	0	_uhttps://doi.org/10.1124/dmd.112.048488 _zAvailable from publisher's website
999			_c22408643 _d22408643