000 02297 a2200589 4500
005 20250516125802.0
264 0 _c20130610
008 201306s 0 0 eng d
022 _a1932-6203
024 7 _a10.1371/journal.pone.0051735
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMisra, Uma K
245 0 0 _aReceptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
_h[electronic resource]
260 _bPloS one
_c2012
300 _ae51735 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAdaptor Proteins, Signal Transducing
_xmetabolism
650 0 4 _aCarrier Proteins
_xmetabolism
650 0 4 _aCell Cycle Proteins
650 0 4 _aCell Line, Tumor
650 0 4 _aEndoplasmic Reticulum Chaperone BiP
650 0 4 _aGene Silencing
650 0 4 _aHeat-Shock Proteins
_xgenetics
650 0 4 _aHumans
650 0 4 _aLow Density Lipoprotein Receptor-Related Protein-1
_xmetabolism
650 0 4 _aMale
650 0 4 _aMechanistic Target of Rapamycin Complex 1
650 0 4 _aMechanistic Target of Rapamycin Complex 2
650 0 4 _aModels, Biological
650 0 4 _aMonomeric GTP-Binding Proteins
_xmetabolism
650 0 4 _aMultiprotein Complexes
_xmetabolism
650 0 4 _aNeuropeptides
_xmetabolism
650 0 4 _aPhosphoproteins
_xmetabolism
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aProstatic Neoplasms
_xgenetics
650 0 4 _aProtein Binding
650 0 4 _aProtein Biosynthesis
650 0 4 _aProto-Oncogene Proteins c-akt
_xmetabolism
650 0 4 _aRNA Interference
650 0 4 _aRapamycin-Insensitive Companion of mTOR Protein
650 0 4 _aRas Homolog Enriched in Brain Protein
650 0 4 _aRegulatory-Associated Protein of mTOR
650 0 4 _aRibosomal Protein S6 Kinases
_xmetabolism
650 0 4 _aSignal Transduction
650 0 4 _aTOR Serine-Threonine Kinases
_xmetabolism
650 0 4 _aTuberous Sclerosis Complex 2 Protein
650 0 4 _aTumor Suppressor Proteins
_xmetabolism
650 0 4 _aalpha-Macroglobulins
_xmetabolism
700 1 _aPizzo, Salvatore V
773 0 _tPloS one
_gvol. 7
_gno. 12
_gp. e51735
856 4 0 _uhttps://doi.org/10.1371/journal.pone.0051735
_zAvailable from publisher's website
999 _c22376674
_d22376674