000			02288 a2200565 4500
005			20250516115539.0
264		0	_c20130225
008			201302s 0 0 eng d
022			_a1873-2968
024	7		_a10.1016/j.bcp.2012.10.009 _2doi
040			_aNLM _beng _cNLM
100	1		_aTsubaki, Masanobu
245	0	0	_aNitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. _h[electronic resource]
260			_bBiochemical pharmacology _cJan 2013
300			_a163-72 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAlendronate _xadverse effects
650	0	4	_aAntineoplastic Agents _xadverse effects
650	0	4	_aApoptosis _xdrug effects
650	0	4	_aApoptosis Regulatory Proteins _xantagonists & inhibitors
650	0	4	_aBcl-2-Like Protein 11
650	0	4	_aBone Density Conservation Agents _xadverse effects
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Nucleus _xdrug effects
650	0	4	_aCell Survival _xdrug effects
650	0	4	_aDiphosphonates _xadverse effects
650	0	4	_aGene Expression Regulation, Neoplastic _xdrug effects
650	0	4	_aGene Silencing
650	0	4	_aHematologic Neoplasms _xdrug therapy
650	0	4	_aHumans
650	0	4	_aImidazoles _xadverse effects
650	0	4	_aMAP Kinase Signaling System _xdrug effects
650	0	4	_aMembrane Proteins _xantagonists & inhibitors
650	0	4	_aNeoplasm Proteins _xantagonists & inhibitors
650	0	4	_aProtein Kinase Inhibitors _xpharmacology
650	0	4	_aProtein Prenylation _xdrug effects
650	0	4	_aProto-Oncogene Proteins _xantagonists & inhibitors
650	0	4	_aProto-Oncogene Proteins p21(ras) _xantagonists & inhibitors
650	0	4	_aSignal Transduction _xdrug effects
650	0	4	_aTOR Serine-Threonine Kinases _xantagonists & inhibitors
700	1		_aItoh, Tatsuki
700	1		_aSatou, Takao
700	1		_aImano, Motohiro
700	1		_aKomai, Makiko
700	1		_aOgawa, Naoki
700	1		_aMukai, Junji
700	1		_aNishida, Shozo
773	0		_tBiochemical pharmacology _gvol. 85 _gno. 2 _gp. 163-72
856	4	0	_uhttps://doi.org/10.1016/j.bcp.2012.10.009 _zAvailable from publisher's website
999			_c22200732 _d22200732