000			02342 a2200697 4500
005			20250516113800.0
264		0	_c20130226
008			201302s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm300931y _2doi
040			_aNLM _beng _cNLM
100	1		_aGerritz, Samuel W
245	0	0	_aAcyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. _h[electronic resource]
260			_bJournal of medicinal chemistry _cNov 2012
300			_a9208-23 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAmyloid Precursor Protein Secretases _xantagonists & inhibitors
650	0	4	_aAmyloid beta-Peptides _xmetabolism
650	0	4	_aAmyloid beta-Protein Precursor _xgenetics
650	0	4	_aAnimals
650	0	4	_aAspartic Acid Endopeptidases _xantagonists & inhibitors
650	0	4	_aBrain _xmetabolism
650	0	4	_aCell Line
650	0	4	_aCrystallography, X-Ray
650	0	4	_aGuanidines _xchemical synthesis
650	0	4	_aHumans
650	0	4	_aIsoxazoles _xchemical synthesis
650	0	4	_aModels, Molecular
650	0	4	_aMolecular Structure
650	0	4	_aMutation
650	0	4	_aPeptide Fragments _xmetabolism
650	0	4	_aProtein Binding
650	0	4	_aRadioligand Assay
650	0	4	_aRats
650	0	4	_aSmall Molecule Libraries
650	0	4	_aSolid-Phase Synthesis Techniques
650	0	4	_aSolutions
650	0	4	_aStructure-Activity Relationship
700	1		_aZhai, Weixu
700	1		_aShi, Shuhao
700	1		_aZhu, Shirong
700	1		_aToyn, Jeremy H
700	1		_aMeredith, Jere E
700	1		_aIben, Lawrence G
700	1		_aBurton, Catherine R
700	1		_aAlbright, Charles F
700	1		_aGood, Andrew C
700	1		_aTebben, Andrew J
700	1		_aMuckelbauer, Jodi K
700	1		_aCamac, Daniel M
700	1		_aMetzler, William
700	1		_aCook, Lynda S
700	1		_aPadmanabha, Ramesh
700	1		_aLentz, Kimberley A
700	1		_aSofia, Michael J
700	1		_aPoss, Michael A
700	1		_aMacor, John E
700	1		_aThompson, Lorin A
773	0		_tJournal of medicinal chemistry _gvol. 55 _gno. 21 _gp. 9208-23
856	4	0	_uhttps://doi.org/10.1021/jm300931y _zAvailable from publisher's website
999			_c22152932 _d22152932