000 01384 a2200385 4500
005 20250516112452.0
264 0 _c20121221
008 201212s 0 0 eng d
022 _a1530-8561
024 7 _a10.1373/clinchem.2012.193698
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSottas, Pierre-Edouard
245 0 0 _aAdaptive Bayesian analysis of serum creatinine as a marker for drug-induced renal impairment in an early-phase clinical trial.
_h[electronic resource]
260 _bClinical chemistry
_cNov 2012
300 _a1592-6 p.
_bdigital
500 _aPublication Type: Clinical Trial, Phase I; Journal Article
650 0 4 _aAdult
650 0 4 _aBayes Theorem
650 0 4 _aBiomarkers, Pharmacological
_xblood
650 0 4 _aCreatinine
_xblood
650 0 4 _aCross-Over Studies
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aDouble-Blind Method
650 0 4 _aDrug-Related Side Effects and Adverse Reactions
_xcomplications
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aReference Values
650 0 4 _aRenal Insufficiency
_xblood
650 0 4 _aRetrospective Studies
650 0 4 _aYoung Adult
700 1 _aKapke, Gordon F
700 1 _aLeroux, Jean-Marc
773 0 _tClinical chemistry
_gvol. 58
_gno. 11
_gp. 1592-6
856 4 0 _uhttps://doi.org/10.1373/clinchem.2012.193698
_zAvailable from publisher's website
999 _c22116822
_d22116822