| 000 | 01066 a2200289 4500 | ||
|---|---|---|---|
| 005 | 20250516110608.0 | ||
| 264 | 0 | _c20121211 | |
| 008 | 201212s 0 0 eng d | ||
| 022 | _a1474-1784 | ||
| 024 | 7 |
_a10.1038/nrd3801 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aMuller, Patrick Y | |
| 245 | 0 | 0 |
_aThe determination and interpretation of the therapeutic index in drug development. _h[electronic resource] |
| 260 |
_bNature reviews. Drug discovery _cOct 2012 |
||
| 300 |
_a751-61 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Review | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aBiomarkers, Pharmacological _xmetabolism |
| 650 | 0 | 4 |
_aDrug Discovery _xtrends |
| 650 | 0 | 4 | _aDrug-Related Side Effects and Adverse Reactions |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aPharmaceutical Preparations _xadministration & dosage |
| 650 | 0 | 4 | _aTreatment Outcome |
| 700 | 1 | _aMilton, Mark N | |
| 773 | 0 |
_tNature reviews. Drug discovery _gvol. 11 _gno. 10 _gp. 751-61 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1038/nrd3801 _zAvailable from publisher's website |
| 999 |
_c22065073 _d22065073 |
||