000 01701 a2200481 4500
005 20250516103559.0
264 0 _c20130317
008 201303s 0 0 eng d
022 _a2045-2322
024 7 _a10.1038/srep00535
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aTohda, Chihiro
245 0 0 _aDiosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.
_h[electronic resource]
260 _bScientific reports
_c2012
300 _a535 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAlzheimer Disease
_xdrug therapy
650 0 4 _aAnimals
650 0 4 _aAntibodies, Monoclonal
_ximmunology
650 0 4 _aAntibodies, Neutralizing
_ximmunology
650 0 4 _aAxons
_xdrug effects
650 0 4 _aCerebellar Cortex
_xdrug effects
650 0 4 _aDiosgenin
_xadministration & dosage
650 0 4 _aDisease Models, Animal
650 0 4 _aFemale
650 0 4 _aGene Knockdown Techniques
650 0 4 _aMale
650 0 4 _aMemory Disorders
_xdrug therapy
650 0 4 _aMice
650 0 4 _aMolecular Docking Simulation
650 0 4 _aNeurons
_xdrug effects
650 0 4 _aPlaque, Amyloid
650 0 4 _aPresynaptic Terminals
_xdrug effects
650 0 4 _aProtein Conformation
650 0 4 _aProtein Disulfide-Isomerases
_xchemistry
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
700 1 _aUrano, Takuya
700 1 _aUmezaki, Masahito
700 1 _aNemere, Ilka
700 1 _aKuboyama, Tomoharu
773 0 _tScientific reports
_gvol. 2
_gp. 535
856 4 0 _uhttps://doi.org/10.1038/srep00535
_zAvailable from publisher's website
999 _c21979558
_d21979558