000			01986 a2200553 4500
005			20250516102205.0
264		0	_c20130207
008			201302s 0 0 eng d
022			_a1873-264X
024	7		_a10.1016/j.jpba.2012.06.027 _2doi
040			_aNLM _beng _cNLM
100	1		_aParekh, Jignesh M
245	0	0	_aDevelopment of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study. _h[electronic resource]
260			_bJournal of pharmaceutical and biomedical analysis _cNov 2012
300			_a462-70 p. _bdigital
500			_aPublication Type: Journal Article; Randomized Controlled Trial
650	0	4	_aAdministration, Oral
650	0	4	_aAdult
650	0	4	_aAntihypertensive Agents _xadministration & dosage
650	0	4	_aArea Under Curve
650	0	4	_aBiotransformation
650	0	4	_aBosentan
650	0	4	_aCalibration
650	0	4	_aChromatography, High Pressure Liquid _xstandards
650	0	4	_aChromatography, Reverse-Phase _xstandards
650	0	4	_aCross-Over Studies
650	0	4	_aFasting _xblood
650	0	4	_aHalf-Life
650	0	4	_aHumans
650	0	4	_aHydroxylation
650	0	4	_aIndia
650	0	4	_aMale
650	0	4	_aMetabolic Clearance Rate
650	0	4	_aReference Standards
650	0	4	_aReproducibility of Results
650	0	4	_aSensitivity and Specificity
650	0	4	_aSolid Phase Extraction _xstandards
650	0	4	_aSulfonamides _xadministration & dosage
650	0	4	_aTablets
650	0	4	_aTandem Mass Spectrometry _xstandards
650	0	4	_aTherapeutic Equivalency
650	0	4	_aYoung Adult
700	1		_aShah, Dhaval K
700	1		_aSanyal, Mallika
700	1		_aYadav, Manish
700	1		_aShrivastav, Pranav S
773	0		_tJournal of pharmaceutical and biomedical analysis _gvol. 70 _gp. 462-70
856	4	0	_uhttps://doi.org/10.1016/j.jpba.2012.06.027 _zAvailable from publisher's website
999			_c21939846 _d21939846