000			02390 a2200673 4500
005			20250516101941.0
264		0	_c20130226
008			201302s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm3007799 _2doi
040			_aNLM _beng _cNLM
100	1		_aVerhoest, Patrick R
245	0	0	_aDesign and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders. _h[electronic resource]
260			_bJournal of medicinal chemistry _cNov 2012
300			_a9045-54 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_a3',5'-Cyclic-AMP Phosphodiesterases _xantagonists & inhibitors
650	0	4	_aAmyloid beta-Protein Precursor _xgenetics
650	0	4	_aAnimals
650	0	4	_aBrain _xmetabolism
650	0	4	_aCatalytic Domain
650	0	4	_aCognition Disorders _xdrug therapy
650	0	4	_aCrystallography, X-Ray
650	0	4	_aCyclic GMP _xmetabolism
650	0	4	_aDogs
650	0	4	_aDrug Design
650	0	4	_aHippocampus _xdrug effects
650	0	4	_aHumans
650	0	4	_aLong-Term Potentiation _xdrug effects
650	0	4	_aMaze Learning _xdrug effects
650	0	4	_aMice
650	0	4	_aMice, Transgenic
650	0	4	_aMicrosomes, Liver _xmetabolism
650	0	4	_aModels, Molecular
650	0	4	_aProtein Conformation
650	0	4	_aPyrazoles _xchemical synthesis
650	0	4	_aPyrimidinones _xchemical synthesis
650	0	4	_aRats
650	0	4	_aStereoisomerism
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSynapses _xdrug effects
700	1		_aFonseca, Kari R
700	1		_aHou, Xinjun
700	1		_aProulx-Lafrance, Caroline
700	1		_aCorman, Michael
700	1		_aHelal, Christopher J
700	1		_aClaffey, Michelle M
700	1		_aTuttle, Jamison B
700	1		_aCoffman, Karen J
700	1		_aLiu, Shenpinq
700	1		_aNelson, Frederick
700	1		_aKleiman, Robin J
700	1		_aMenniti, Frank S
700	1		_aSchmidt, Christopher J
700	1		_aVanase-Frawley, Michelle
700	1		_aLiras, Spiros
773	0		_tJournal of medicinal chemistry _gvol. 55 _gno. 21 _gp. 9045-54
856	4	0	_uhttps://doi.org/10.1021/jm3007799 _zAvailable from publisher's website
999			_c21932738 _d21932738