000 02140 a2200625 4500
005 20250516101933.0
264 0 _c20121105
008 201211s 0 0 eng d
022 _a1520-4804
024 7 _a10.1021/jm300353r
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aQin, Zhihui
245 0 0 _aDesign and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cAug 2012
300 _a6784-801 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAlzheimer Disease
_xdrug therapy
650 0 4 _aAmyloid beta-Protein Precursor
_xgenetics
650 0 4 _aAnimals
650 0 4 _aAvoidance Learning
_xdrug effects
650 0 4 _aBiological Availability
650 0 4 _aBrain
_xmetabolism
650 0 4 _aClick Chemistry
650 0 4 _aCognition Disorders
_xdrug therapy
650 0 4 _aGlucose
_xdeficiency
650 0 4 _aHippocampus
_xdrug effects
650 0 4 _aHumans
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMice, Transgenic
650 0 4 _aMolecular Mimicry
650 0 4 _aMutation
650 0 4 _aNeurons
_xcytology
650 0 4 _aNeuroprotective Agents
_xchemical synthesis
650 0 4 _aNitric Oxide
_xchemistry
650 0 4 _aOxygen
_xmetabolism
650 0 4 _aPrimary Cell Culture
650 0 4 _aProdrugs
_xchemical synthesis
650 0 4 _aReceptors, GABA-A
_xmetabolism
650 0 4 _aSmall Molecule Libraries
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSynaptic Transmission
_xdrug effects
650 0 4 _aThiazoles
_xchemical synthesis
650 0 4 _aTissue Distribution
700 1 _aLuo, Jia
700 1 _aVandeVrede, Lawren
700 1 _aTavassoli, Ehsan
700 1 _aFa', Mauro
700 1 _aTeich, Andrew F
700 1 _aArancio, Ottavio
700 1 _aThatcher, Gregory R J
773 0 _tJournal of medicinal chemistry
_gvol. 55
_gno. 15
_gp. 6784-801
856 4 0 _uhttps://doi.org/10.1021/jm300353r
_zAvailable from publisher's website
999 _c21932344
_d21932344