| 000 | 02734 a2200793 4500 | ||
|---|---|---|---|
| 005 | 20250516101013.0 | ||
| 264 | 0 | _c20121105 | |
| 008 | 201211s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm300411k _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aKosugi, Tomomi | |
| 245 | 0 | 0 |
_aMitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cAug 2012 |
||
| 300 |
_a6700-15 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aAnti-Inflammatory Agents, Non-Steroidal _xchemical synthesis |
| 650 | 0 | 4 | _aCell Line |
| 650 | 0 | 4 | _aCrystallography, X-Ray |
| 650 | 0 | 4 |
_aHSP27 Heat-Shock Proteins _xmetabolism |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aIntracellular Signaling Peptides and Proteins _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aLipopolysaccharides _xpharmacology |
| 650 | 0 | 4 | _aMale |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMice, Inbred C57BL |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aPhosphorylation |
| 650 | 0 | 4 | _aProtein Conformation |
| 650 | 0 | 4 |
_aProtein Serine-Threonine Kinases _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aPyrazoles _xchemical synthesis |
| 650 | 0 | 4 |
_aPyrimidines _xchemical synthesis |
| 650 | 0 | 4 |
_aShock, Septic _xmetabolism |
| 650 | 0 | 4 | _aSmall Molecule Libraries |
| 650 | 0 | 4 | _aStereoisomerism |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aTumor Necrosis Factor-alpha _xbiosynthesis |
| 700 | 1 | _aMitchell, Dale R | |
| 700 | 1 | _aFujino, Aiko | |
| 700 | 1 | _aImai, Minoru | |
| 700 | 1 | _aKambe, Mika | |
| 700 | 1 | _aKobayashi, Shinji | |
| 700 | 1 | _aMakino, Hiroaki | |
| 700 | 1 | _aMatsueda, Yohei | |
| 700 | 1 | _aOue, Yasuhiro | |
| 700 | 1 | _aKomatsu, Kanji | |
| 700 | 1 | _aImaizumi, Keiichiro | |
| 700 | 1 | _aSakai, Yuri | |
| 700 | 1 | _aSugiura, Satoshi | |
| 700 | 1 | _aTakenouchi, Osami | |
| 700 | 1 | _aUnoki, Gen | |
| 700 | 1 | _aYamakoshi, Yuko | |
| 700 | 1 | _aCunliffe, Vicky | |
| 700 | 1 | _aFrearson, Julie | |
| 700 | 1 | _aGordon, Richard | |
| 700 | 1 | _aHarris, C John | |
| 700 | 1 | _aKalloo-Hosein, Heidi | |
| 700 | 1 | _aLe, Joelle | |
| 700 | 1 | _aPatel, Gita | |
| 700 | 1 | _aSimpson, Donald J | |
| 700 | 1 | _aSherborne, Brad | |
| 700 | 1 | _aThomas, Peter S | |
| 700 | 1 | _aSuzuki, Naotaka | |
| 700 | 1 | _aTakimoto-Kamimura, Midori | |
| 700 | 1 | _aKataoka, Ken-ichiro | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 55 _gno. 15 _gp. 6700-15 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm300411k _zAvailable from publisher's website |
| 999 |
_c21906595 _d21906595 |
||