000 01901 a2200565 4500
005 20250516084122.0
264 0 _c20120625
008 201206s 0 0 eng d
022 _a1532-1827
024 7 _a10.1038/bjc.2012.85
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGallardo, A
245 0 0 _aIncreased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.
_h[electronic resource]
260 _bBritish journal of cancer
_cApr 2012
300 _a1367-73 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdult
650 0 4 _aAged
650 0 4 _aAged, 80 and over
650 0 4 _aAntibodies, Monoclonal, Humanized
_xpharmacology
650 0 4 _aBreast Neoplasms
_xdiagnosis
650 0 4 _aDrug Resistance, Neoplasm
_xdrug effects
650 0 4 _aErbB Receptors
_xmetabolism
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aMiddle Aged
650 0 4 _aNeoplasm Staging
650 0 4 _aPTEN Phosphohydrolase
_xmetabolism
650 0 4 _aPhosphatidylinositol 3-Kinases
_xgenetics
650 0 4 _aPrognosis
650 0 4 _aProto-Oncogene Proteins c-akt
_xmetabolism
650 0 4 _aReceptor, ErbB-2
_xgenetics
650 0 4 _aReceptor, IGF Type 1
_xmetabolism
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSurvival Analysis
650 0 4 _aTrastuzumab
700 1 _aLerma, E
700 1 _aEscuin, D
700 1 _aTibau, A
700 1 _aMuñoz, J
700 1 _aOjeda, B
700 1 _aBarnadas, A
700 1 _aAdrover, E
700 1 _aSánchez-Tejada, L
700 1 _aGiner, D
700 1 _aOrtiz-Martínez, F
700 1 _aPeiró, G
773 0 _tBritish journal of cancer
_gvol. 106
_gno. 8
_gp. 1367-73
856 4 0 _uhttps://doi.org/10.1038/bjc.2012.85
_zAvailable from publisher's website
999 _c21657338
_d21657338