000			02164 a2200577 4500
005			20250516081645.0
264		0	_c20120716
008			201207s 0 0 eng d
022			_a1879-114X
024	7		_a10.1016/j.clinthera.2012.01.022 _2doi
040			_aNLM _beng _cNLM
100	1		_aTong, Gary
245	0	0	_aMulticenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers. _h[electronic resource]
260			_bClinical therapeutics _cMar 2012
300			_a654-67 p. _bdigital
500			_aPublication Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Oral
650	0	4	_aAdolescent
650	0	4	_aAdult
650	0	4	_aAmyloid Precursor Protein Secretases _xantagonists & inhibitors
650	0	4	_aAmyloid beta-Peptides _xblood
650	0	4	_aBasic Helix-Loop-Helix Transcription Factors _xblood
650	0	4	_aBiomarkers _xanalysis
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDual Specificity Phosphatase 6 _xblood
650	0	4	_aHomeodomain Proteins _xblood
650	0	4	_aHumans
650	0	4	_aMale
650	0	4	_aOxadiazoles _xadministration & dosage
650	0	4	_aPeptide Fragments _xblood
650	0	4	_aPeptides _xblood
650	0	4	_aSulfonamides _xadministration & dosage
650	0	4	_aTranscription Factor HES-1
650	0	4	_aTrefoil Factor-3
650	0	4	_aYoung Adult
700	1		_aWang, Jun-Sheng
700	1		_aSverdlov, Oleksandr
700	1		_aHuang, Shu-Pang
700	1		_aSlemmon, Randy
700	1		_aCroop, Robert
700	1		_aCastaneda, Lorna
700	1		_aGu, Huidong
700	1		_aWong, Oi
700	1		_aLi, Hewei
700	1		_aBerman, Robert M
700	1		_aSmith, Christina
700	1		_aAlbright, Charles F
700	1		_aDockens, Randy C
773	0		_tClinical therapeutics _gvol. 34 _gno. 3 _gp. 654-67
856	4	0	_uhttps://doi.org/10.1016/j.clinthera.2012.01.022 _zAvailable from publisher's website
999			_c21588931 _d21588931