000 01915 a2200529 4500
005 20250516074704.0
264 0 _c20120523
008 201205s 0 0 eng d
022 _a1872-7786
024 7 _a10.1016/j.cbi.2012.01.004
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGherezghiher, Teshome B
245 0 0 _aThe naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
_h[electronic resource]
260 _bChemico-biological interactions
_cMar 2012
300 _a1-10 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAnimals
650 0 4 _aAryl Hydrocarbon Hydroxylases
_xmetabolism
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aCytochrome P-450 CYP1B1
650 0 4 _aCytochrome P-450 CYP3A
_xmetabolism
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aEquilenin
_xanalogs & derivatives
650 0 4 _aFemale
650 0 4 _aHalf-Life
650 0 4 _aInhibitory Concentration 50
650 0 4 _aKinetics
650 0 4 _aMagnetic Resonance Spectroscopy
650 0 4 _aMicrosomes, Liver
650 0 4 _aNaphthalenes
_xchemistry
650 0 4 _aOxidation-Reduction
650 0 4 _aPiperidines
_xchemistry
650 0 4 _aQuinones
_xchemistry
650 0 4 _aRats
650 0 4 _aRats, Sprague-Dawley
650 0 4 _aSelective Estrogen Receptor Modulators
_xchemistry
650 0 4 _aTandem Mass Spectrometry
700 1 _aMichalsen, Bradley
700 1 _aChandrasena, R Esala P
700 1 _aQin, Zhihui
700 1 _aSohn, Johann
700 1 _aThatcher, Gregory R J
700 1 _aBolton, Judy L
773 0 _tChemico-biological interactions
_gvol. 196
_gno. 1-2
_gp. 1-10
856 4 0 _uhttps://doi.org/10.1016/j.cbi.2012.01.004
_zAvailable from publisher's website
999 _c21503556
_d21503556