000			02285 a2200613 4500
005			20250516073114.0
264		0	_c20130603
008			201306s 0 0 eng d
022			_a1880-0920
024	7		_a10.2133/dmpk.dmpk-11-rg-101 _2doi
040			_aNLM _beng _cNLM
100	1		_aOnoue, Satomi
245	0	0	_aPhysicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. _h[electronic resource]
260			_bDrug metabolism and pharmacokinetics _c2012
300			_a379-87 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Oral
650	0	4	_aAnimals
650	0	4	_aAnti-Inflammatory Agents, Non-Steroidal _xadministration & dosage
650	0	4	_aArea Under Curve
650	0	4	_aBiological Availability
650	0	4	_aCalorimetry, Differential Scanning
650	0	4	_aChemistry, Pharmaceutical
650	0	4	_aChromatography, Liquid
650	0	4	_aCrystallization
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDrug Stability
650	0	4	_aGastric Juice _xchemistry
650	0	4	_aHydrogen-Ion Concentration
650	0	4	_aHydrophobic and Hydrophilic Interactions
650	0	4	_aInjections, Intravenous
650	0	4	_aMale
650	0	4	_aMetabolic Clearance Rate
650	0	4	_aMicroscopy, Electron, Scanning
650	0	4	_aMicroscopy, Polarization
650	0	4	_aModels, Biological
650	0	4	_aPolymethacrylic Acids _xchemistry
650	0	4	_aPowder Diffraction
650	0	4	_aRats
650	0	4	_aRats, Sprague-Dawley
650	0	4	_aSolubility
650	0	4	_aSpectrometry, Mass, Electrospray Ionization
650	0	4	_aSpectroscopy, Fourier Transform Infrared
650	0	4	_aSpectroscopy, Near-Infrared
650	0	4	_aTechnology, Pharmaceutical _xmethods
650	0	4	_aortho-Aminobenzoates _xadministration & dosage
700	1		_aKojo, Yoshiki
700	1		_aAoki, Yosuke
700	1		_aKawabata, Yohei
700	1		_aYamauchi, Yukinori
700	1		_aYamada, Shizuo
773	0		_tDrug metabolism and pharmacokinetics _gvol. 27 _gno. 4 _gp. 379-87
856	4	0	_uhttps://doi.org/10.2133/dmpk.dmpk-11-rg-101 _zAvailable from publisher's website
999			_c21457130 _d21457130