000			02001 a2200565 4500
005			20250516070443.0
264		0	_c20130404
008			201304s 0 0 eng d
022			_a1573-0646
024	7		_a10.1007/s10637-011-9774-6 _2doi
040			_aNLM _beng _cNLM
100	1		_aWeiss, Glen J
245	0	0	_aPhase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies. _h[electronic resource]
260			_bInvestigational new drugs _cDec 2012
300			_a2334-43 p. _bdigital
500			_aPublication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study
650	0	4	_aAdolescent
650	0	4	_aAdult
650	0	4	_aAged
650	0	4	_aCyclin-Dependent Kinases _xantagonists & inhibitors
650	0	4	_aDrug Administration Schedule
650	0	4	_aFemale
650	0	4	_aHumans
650	0	4	_aMale
650	0	4	_aMaximum Tolerated Dose
650	0	4	_aMiddle Aged
650	0	4	_aNeoplasms _xdrug therapy
650	0	4	_aProtein Kinase Inhibitors _xadministration & dosage
650	0	4	_aPyrazoles _xadministration & dosage
650	0	4	_aQuinazolines _xadministration & dosage
650	0	4	_aReceptor, trkA _xantagonists & inhibitors
650	0	4	_aTreatment Outcome
650	0	4	_aYoung Adult
700	1		_aHidalgo, Manuel
700	1		_aBorad, Mitesh J
700	1		_aLaheru, Daniel
700	1		_aTibes, Raoul
700	1		_aRamanathan, Ramesh K
700	1		_aBlaydorn, Lisa
700	1		_aJameson, Gayle
700	1		_aJimeno, Antonio
700	1		_aIsaacs, Jeffrey D
700	1		_aScaburri, Angela
700	1		_aPacciarini, Maria Adele
700	1		_aFiorentini, Francesco
700	1		_aCiomei, Marina
700	1		_aVon Hoff, Daniel D
773	0		_tInvestigational new drugs _gvol. 30 _gno. 6 _gp. 2334-43
856	4	0	_uhttps://doi.org/10.1007/s10637-011-9774-6 _zAvailable from publisher's website
999			_c21383693 _d21383693