000 01672 a2200433 4500
005 20250516070058.0
264 0 _c20120325
008 201203s 0 0 eng d
022 _a1083-351X
024 7 _a10.1074/jbc.M111.309369
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKoole, Cassandra
245 0 0 _aSecond extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
_h[electronic resource]
260 _bThe Journal of biological chemistry
_cFeb 2012
300 _a3659-73 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAllosteric Regulation
650 0 4 _aAmino Acid Substitution
650 0 4 _aBiomimetic Materials
_xchemistry
650 0 4 _aCell Line
650 0 4 _aGlucagon-Like Peptide-1 Receptor
650 0 4 _aHumans
650 0 4 _aMAP Kinase Signaling System
_xdrug effects
650 0 4 _aMitogen-Activated Protein Kinase 1
_xchemistry
650 0 4 _aMitogen-Activated Protein Kinase 3
_xchemistry
650 0 4 _aMutation, Missense
650 0 4 _aPeptides
_xchemistry
650 0 4 _aProtein Structure, Secondary
650 0 4 _aProtein Structure, Tertiary
650 0 4 _aReceptors, Glucagon
_xchemistry
700 1 _aWootten, Denise
700 1 _aSimms, John
700 1 _aSavage, Emilia E
700 1 _aMiller, Laurence J
700 1 _aChristopoulos, Arthur
700 1 _aSexton, Patrick M
773 0 _tThe Journal of biological chemistry
_gvol. 287
_gno. 6
_gp. 3659-73
856 4 0 _uhttps://doi.org/10.1074/jbc.M111.309369
_zAvailable from publisher's website
999 _c21371490
_d21371490