000 01932 a2200517 4500
005 20250516064739.0
264 0 _c20120413
008 201204s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.1117773108
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aWise, David R
245 0 0 _aHypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_cDec 2011
300 _a19611-6 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aCarboxylic Acids
_xmetabolism
650 0 4 _aCell Hypoxia
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Proliferation
650 0 4 _aCell Survival
650 0 4 _aCitrates
_xmetabolism
650 0 4 _aCitric Acid Cycle
650 0 4 _aGas Chromatography-Mass Spectrometry
650 0 4 _aGlucose
_xmetabolism
650 0 4 _aGlutamine
_xmetabolism
650 0 4 _aHumans
650 0 4 _aHypoxia-Inducible Factor 1
_xgenetics
650 0 4 _aImmunoblotting
650 0 4 _aIsocitrate Dehydrogenase
_xgenetics
650 0 4 _aKetoglutaric Acids
_xmetabolism
650 0 4 _aNeoplasms
_xgenetics
650 0 4 _aOxidation-Reduction
650 0 4 _aRNA Interference
700 1 _aWard, Patrick S
700 1 _aShay, Jessica E S
700 1 _aCross, Justin R
700 1 _aGruber, Joshua J
700 1 _aSachdeva, Uma M
700 1 _aPlatt, Jesse M
700 1 _aDeMatteo, Raymond G
700 1 _aSimon, M Celeste
700 1 _aThompson, Craig B
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 108
_gno. 49
_gp. 19611-6
856 4 0 _uhttps://doi.org/10.1073/pnas.1117773108
_zAvailable from publisher's website
999 _c21333136
_d21333136