000 02413 a2200613 4500
005 20250516025842.0
264 0 _c20110915
008 201109s 0 0 eng d
022 _a1557-3265
024 7 _a10.1158/1078-0432.CCR-10-2580
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aRajeshkumar, N V
245 0 0 _aMK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
_h[electronic resource]
260 _bClinical cancer research : an official journal of the American Association for Cancer Research
_cMay 2011
300 _a2799-806 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Combined Chemotherapy Protocols
_xtherapeutic use
650 0 4 _aCarcinoma, Pancreatic Ductal
_xdrug therapy
650 0 4 _aCell Cycle Proteins
_xantagonists & inhibitors
650 0 4 _aCell Line, Tumor
650 0 4 _aDeoxycytidine
_xadministration & dosage
650 0 4 _aDisease Progression
650 0 4 _aDrug Synergism
650 0 4 _aFemale
650 0 4 _aGenes, p53
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aMice, Nude
650 0 4 _aMutation
_xphysiology
650 0 4 _aNeoplasms
_xdrug therapy
650 0 4 _aNuclear Proteins
_xantagonists & inhibitors
650 0 4 _aPancreatic Neoplasms
_xdrug therapy
650 0 4 _aProtein Kinase Inhibitors
_xadministration & dosage
650 0 4 _aProtein-Tyrosine Kinases
_xantagonists & inhibitors
650 0 4 _aPyrazoles
_xadministration & dosage
650 0 4 _aPyrimidines
_xadministration & dosage
650 0 4 _aPyrimidinones
650 0 4 _aTumor Burden
_xdrug effects
650 0 4 _aXenograft Model Antitumor Assays
650 0 4 _aGemcitabine
700 1 _aDe Oliveira, Elizabeth
700 1 _aOttenhof, Niki
700 1 _aWatters, James
700 1 _aBrooks, David
700 1 _aDemuth, Tim
700 1 _aShumway, Stuart D
700 1 _aMizuarai, Shinji
700 1 _aHirai, Hiroshi
700 1 _aMaitra, Anirban
700 1 _aHidalgo, Manuel
773 0 _tClinical cancer research : an official journal of the American Association for Cancer Research
_gvol. 17
_gno. 9
_gp. 2799-806
856 4 0 _uhttps://doi.org/10.1158/1078-0432.CCR-10-2580
_zAvailable from publisher's website
999 _c20661440
_d20661440