000			01501 a2200409 4500
005			20250516025329.0
264		0	_c20110616
008			201106s 0 0 eng d
022			_a1557-7988
024	7		_a10.1016/B978-0-12-381274-2.00019-4 _2doi
040			_aNLM _beng _cNLM
100	1		_aAbad, Marta C
245	0	0	_aElectron density guided fragment-based drug design--a lead generation example. _h[electronic resource]
260			_bMethods in enzymology _c2011
300			_a487-508 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
650	0	4	_aAdenosine Triphosphate _xmetabolism
650	0	4	_aAdenylyl Imidodiphosphate _xmetabolism
650	0	4	_aCatalytic Domain _xdrug effects
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDrug Design
650	0	4	_aDrug Discovery
650	0	4	_aDrug Evaluation, Preclinical _xmethods
650	0	4	_aElectrons
650	0	4	_aEnzyme Inhibitors _xchemistry
650	0	4	_aFructokinases _xantagonists & inhibitors
650	0	4	_aFructose _xmetabolism
650	0	4	_aHydrogen Bonding
650	0	4	_aModels, Molecular
650	0	4	_aProtein Binding
650	0	4	_aSmall Molecule Libraries
650	0	4	_aSulfates _xchemistry
700	1		_aGibbs, Alan C
700	1		_aZhang, Xuqing
773	0		_tMethods in enzymology _gvol. 493 _gp. 487-508
856	4	0	_uhttps://doi.org/10.1016/B978-0-12-381274-2.00019-4 _zAvailable from publisher's website
999			_c20644520 _d20644520