000			02155 a2200589 4500
005			20250516014951.0
264		0	_c20110106
008			201101s 0 0 eng d
022			_a1878-3686
024	7		_a10.1016/j.ccr.2010.11.023 _2doi
040			_aNLM _beng _cNLM
100	1		_aVillanueva, Jessie
245	0	0	_aAcquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. _h[electronic resource]
260			_bCancer cell _cDec 2010
300			_a683-95 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650	0	4	_aCell Line, Tumor
650	0	4	_aDrug Resistance, Neoplasm
650	0	4	_aHumans
650	0	4	_aMAP Kinase Signaling System
650	0	4	_aMelanoma _xdrug therapy
650	0	4	_aMitogen-Activated Protein Kinase Kinases _xantagonists & inhibitors
650	0	4	_aPhosphatidylinositol 3-Kinases _xphysiology
650	0	4	_aPhosphoinositide-3 Kinase Inhibitors
650	0	4	_aPhosphorylation
650	0	4	_aProto-Oncogene Proteins B-raf _xantagonists & inhibitors
650	0	4	_aProto-Oncogene Proteins c-akt _xmetabolism
650	0	4	_aReceptor, IGF Type 1 _xantagonists & inhibitors
650	0	4	_araf Kinases _xphysiology
700	1		_aVultur, Adina
700	1		_aLee, John T
700	1		_aSomasundaram, Rajasekharan
700	1		_aFukunaga-Kalabis, Mizuho
700	1		_aCipolla, Angela K
700	1		_aWubbenhorst, Bradley
700	1		_aXu, Xiaowei
700	1		_aGimotty, Phyllis A
700	1		_aKee, Damien
700	1		_aSantiago-Walker, Ademi E
700	1		_aLetrero, Richard
700	1		_aD'Andrea, Kurt
700	1		_aPushparajan, Anitha
700	1		_aHayden, James E
700	1		_aBrown, Kimberly Dahlman
700	1		_aLaquerre, Sylvie
700	1		_aMcArthur, Grant A
700	1		_aSosman, Jeffrey A
700	1		_aNathanson, Katherine L
700	1		_aHerlyn, Meenhard
773	0		_tCancer cell _gvol. 18 _gno. 6 _gp. 683-95
856	4	0	_uhttps://doi.org/10.1016/j.ccr.2010.11.023 _zAvailable from publisher's website
999			_c20445739 _d20445739