000 02725 a2200745 4500
005 20250516002622.0
264 0 _c20101215
008 201012s 0 0 eng d
022 _a1524-4571
024 7 _a10.1161/CIRCRESAHA.110.229054
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGuo, Danny
245 0 0 _aLoss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.
_h[electronic resource]
260 _bCirculation research
_cNov 2010
300 _a1275-89 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdrenergic beta-Antagonists
_xadministration & dosage
650 0 4 _aAnimals
650 0 4 _aAntigens, CD
_xmetabolism
650 0 4 _aBiomechanical Phenomena
650 0 4 _aCadherins
_xmetabolism
650 0 4 _aCardiomegaly
_xdrug therapy
650 0 4 _aCell Adhesion
650 0 4 _aCells, Cultured
650 0 4 _aClass Ib Phosphatidylinositol 3-Kinase
_xdeficiency
650 0 4 _aCyclic AMP
_xmetabolism
650 0 4 _aCyclic AMP Response Element-Binding Protein
_xmetabolism
650 0 4 _aDisease Models, Animal
650 0 4 _aExtracellular Matrix
_xmetabolism
650 0 4 _aFibroblasts
_xenzymology
650 0 4 _aGlycogen Synthase Kinase 3
_xmetabolism
650 0 4 _aHeart Failure
_xenzymology
650 0 4 _aMale
650 0 4 _aMatrix Metalloproteinase 13
_xmetabolism
650 0 4 _aMatrix Metalloproteinase 14
_xmetabolism
650 0 4 _aMatrix Metalloproteinase 2
_xmetabolism
650 0 4 _aMatrix Metalloproteinases
_xmetabolism
650 0 4 _aMechanotransduction, Cellular
_xdrug effects
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMice, Knockout
650 0 4 _aMyocardial Contraction
650 0 4 _aMyocardium
_xenzymology
650 0 4 _aMyocytes, Cardiac
_xenzymology
650 0 4 _aPhosphorylation
650 0 4 _aPropranolol
_xadministration & dosage
650 0 4 _aProto-Oncogene Proteins c-akt
_xmetabolism
650 0 4 _aStress, Mechanical
650 0 4 _aTime Factors
650 0 4 _aVentricular Remodeling
_xdrug effects
650 0 4 _abeta Catenin
_xmetabolism
700 1 _aKassiri, Zamaneh
700 1 _aBasu, Ratnadeep
700 1 _aChow, Fung L
700 1 _aKandalam, Vijay
700 1 _aDamilano, Federico
700 1 _aLiang, Wenbin
700 1 _aIzumo, Seigo
700 1 _aHirsch, Emilio
700 1 _aPenninger, Josef M
700 1 _aBackx, Peter H
700 1 _aOudit, Gavin Y
773 0 _tCirculation research
_gvol. 107
_gno. 10
_gp. 1275-89
856 4 0 _uhttps://doi.org/10.1161/CIRCRESAHA.110.229054
_zAvailable from publisher's website
999 _c20177803
_d20177803