000			02047 a2200553 4500
005			20250515230942.0
264		0	_c20100825
008			201008s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm1001088 _2doi
040			_aNLM _beng _cNLM
100	1		_aDrews, Andreas
245	0	0	_a1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. _h[electronic resource]
260			_bJournal of medicinal chemistry _cJul 2010
300			_a5165-78 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Topical
650	0	4	_aAnimals
650	0	4	_aAnti-Inflammatory Agents, Non-Steroidal _xchemical synthesis
650	0	4	_aBile _xmetabolism
650	0	4	_aBiological Availability
650	0	4	_aBlood Platelets _xdrug effects
650	0	4	_aCytosol _xenzymology
650	0	4	_aDermatitis, Contact _xdrug therapy
650	0	4	_aDrug Stability
650	0	4	_aGlucuronides _xmetabolism
650	0	4	_aGroup IV Phospholipases A2 _xantagonists & inhibitors
650	0	4	_aHumans
650	0	4	_aIndoles _xchemical synthesis
650	0	4	_aMice
650	0	4	_aMice, Inbred C57BL
650	0	4	_aMicrosomes, Liver _xmetabolism
650	0	4	_aPhenyl Ethers _xchemical synthesis
650	0	4	_aRats
650	0	4	_aSolubility
650	0	4	_aStructure-Activity Relationship
650	0	4	_aThermodynamics
700	1		_aBovens, Stefanie
700	1		_aRoebrock, Kirsten
700	1		_aSunderkötter, Cord
700	1		_aReinhardt, Dirk
700	1		_aSchäfers, Michael
700	1		_avan der Velde, Andrea
700	1		_aSchulze Elfringhoff, Alwine
700	1		_aFabian, Jörg
700	1		_aLehr, Matthias
773	0		_tJournal of medicinal chemistry _gvol. 53 _gno. 14 _gp. 5165-78
856	4	0	_uhttps://doi.org/10.1021/jm1001088 _zAvailable from publisher's website
999			_c19931380 _d19931380