000 01990 a2200517 4500
005 20250515223852.0
264 0 _c20100617
008 201006s 0 0 eng d
022 _a1538-7445
024 7 _a10.1158/0008-5472.CAN-09-1107
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aFeldmann, Georg
245 0 0 _aInhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling.
_h[electronic resource]
260 _bCancer research
_cJun 2010
300 _a4460-9 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAdaptor Proteins, Signal Transducing
_xbiosynthesis
650 0 4 _aAnimals
650 0 4 _aCell Cycle Proteins
_xbiosynthesis
650 0 4 _aCell Growth Processes
_xdrug effects
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Movement
_xdrug effects
650 0 4 _aCyclin-Dependent Kinase 5
_xantagonists & inhibitors
650 0 4 _aDown-Regulation
650 0 4 _aGene Knockdown Techniques
650 0 4 _aHumans
650 0 4 _aMAP Kinase Signaling System
_xdrug effects
650 0 4 _aMice
650 0 4 _aPancreatic Neoplasms
_xenzymology
650 0 4 _aPhosphatidylinositol 3-Kinases
_xmetabolism
650 0 4 _aProto-Oncogene Proteins c-akt
_xmetabolism
650 0 4 _aSignal Transduction
650 0 4 _aXenograft Model Antitumor Assays
650 0 4 _aral GTP-Binding Proteins
_xantagonists & inhibitors
650 0 4 _aras Proteins
_xantagonists & inhibitors
700 1 _aMishra, Anjali
700 1 _aHong, Seung-Mo
700 1 _aBisht, Savita
700 1 _aStrock, Christopher J
700 1 _aBall, Douglas W
700 1 _aGoggins, Michael
700 1 _aMaitra, Anirban
700 1 _aNelkin, Barry D
773 0 _tCancer research
_gvol. 70
_gno. 11
_gp. 4460-9
856 4 0 _uhttps://doi.org/10.1158/0008-5472.CAN-09-1107
_zAvailable from publisher's website
999 _c19837828
_d19837828