| 000 | 02494 a2200781 4500 | ||
|---|---|---|---|
| 005 | 20250515210614.0 | ||
| 264 | 0 | _c20100504 | |
| 008 | 201005s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm100022r _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aShen, Hong C | |
| 245 | 0 | 0 |
_aDiscovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cMar 2010 |
||
| 300 |
_a2666-70 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aArea Under Curve |
| 650 | 0 | 4 | _aBinding, Competitive |
| 650 | 0 | 4 | _aCHO Cells |
| 650 | 0 | 4 |
_aCarboxylic Acids _xchemistry |
| 650 | 0 | 4 | _aCricetinae |
| 650 | 0 | 4 | _aCricetulus |
| 650 | 0 | 4 |
_aCyclohexanecarboxylic Acids _xchemistry |
| 650 | 0 | 4 |
_aCyclohexenes _xchemistry |
| 650 | 0 | 4 | _aDogs |
| 650 | 0 | 4 | _aDrug Discovery |
| 650 | 0 | 4 | _aDrug Evaluation, Preclinical |
| 650 | 0 | 4 |
_aFatty Acids, Nonesterified _xblood |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aMetabolic Clearance Rate |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMice, Inbred C57BL |
| 650 | 0 | 4 | _aMice, Knockout |
| 650 | 0 | 4 | _aModels, Chemical |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 |
_aOxadiazoles _xchemistry |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 |
_aReceptors, G-Protein-Coupled _xagonists |
| 650 | 0 | 4 |
_aReceptors, Nicotinic _xgenetics |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aVasodilation _xdrug effects |
| 700 | 1 | _aDing, Fa-Xiang | |
| 700 | 1 | _aRaghavan, Subharekha | |
| 700 | 1 | _aDeng, Qiaolin | |
| 700 | 1 | _aLuell, Silvi | |
| 700 | 1 | _aForrest, Michael J | |
| 700 | 1 | _aCarballo-Jane, Ester | |
| 700 | 1 | _aWilsie, Larissa C | |
| 700 | 1 | _aKrsmanovic, Mihajlo L | |
| 700 | 1 | _aTaggart, Andrew K | |
| 700 | 1 | _aWu, Kenneth K | |
| 700 | 1 | _aWu, Tsuei-Ju | |
| 700 | 1 | _aCheng, Kang | |
| 700 | 1 | _aRen, Ning | |
| 700 | 1 | _aCai, Tian-Quan | |
| 700 | 1 | _aChen, Qing | |
| 700 | 1 | _aWang, Junying | |
| 700 | 1 | _aWolff, Michael S | |
| 700 | 1 | _aTong, Xinchun | |
| 700 | 1 | _aHolt, Tom G | |
| 700 | 1 | _aWaters, M Gerard | |
| 700 | 1 | _aHammond, Milton L | |
| 700 | 1 | _aTata, James R | |
| 700 | 1 | _aColletti, Steven L | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 53 _gno. 6 _gp. 2666-70 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm100022r _zAvailable from publisher's website |
| 999 |
_c19552707 _d19552707 |
||