000			02230 a2200589 4500
005			20250515204709.0
264		0	_c20100917
008			201009s 0 0 eng d
022			_a1521-009X
024	7		_a10.1124/dmd.109.031252 _2doi
040			_aNLM _beng _cNLM
100	1		_aVourvahis, Manoli
245	0	0	_aExcretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. _h[electronic resource]
260			_bDrug metabolism and disposition: the biological fate of chemicals _cMay 2010
300			_a789-800 p. _bdigital
500			_aPublication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdult
650	0	4	_aAnti-HIV Agents _xadverse effects
650	0	4	_aArea Under Curve
650	0	4	_aBiocatalysis
650	0	4	_aCytochrome P-450 CYP3A _xmetabolism
650	0	4	_aDealkylation
650	0	4	_aFeces _xchemistry
650	0	4	_aGlucuronidase _xmetabolism
650	0	4	_aGlucuronides _xanalysis
650	0	4	_aGlucuronosyltransferase _xmetabolism
650	0	4	_aHumans
650	0	4	_aHydrolysis
650	0	4	_aHydroxylation
650	0	4	_aKinetics
650	0	4	_aMale
650	0	4	_aMicrosomes, Liver _xenzymology
650	0	4	_aMiddle Aged
650	0	4	_aMolecular Structure
650	0	4	_aNitriles _xadverse effects
650	0	4	_aOxidation-Reduction
650	0	4	_aPyrazoles _xadverse effects
650	0	4	_aRecombinant Proteins _xmetabolism
650	0	4	_aReverse Transcriptase Inhibitors _xadverse effects
650	0	4	_aSulfates _xmetabolism
650	0	4	_aTandem Mass Spectrometry
700	1		_aGleave, Michelle
700	1		_aNedderman, Angus N R
700	1		_aHyland, Ruth
700	1		_aGardner, Iain
700	1		_aHoward, Martin
700	1		_aKempshall, Sarah
700	1		_aCollins, Claire
700	1		_aLaBadie, Robert
773	0		_tDrug metabolism and disposition: the biological fate of chemicals _gvol. 38 _gno. 5 _gp. 789-800
856	4	0	_uhttps://doi.org/10.1124/dmd.109.031252 _zAvailable from publisher's website
999			_c19496494 _d19496494