000			02245 a2200601 4500
005			20250515201322.0
264		0	_c20110906
008			201109s 0 0 eng d
022			_a1573-0646
024	7		_a10.1007/s10637-009-9356-z _2doi
040			_aNLM _beng _cNLM
100	1		_aHong, Bo
245	0	0	_aHypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation. _h[electronic resource]
260			_bInvestigational new drugs _cJun 2011
300			_a401-10 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAntineoplastic Agents _xpharmacology
650	0	4	_aApoptosis _xdrug effects
650	0	4	_aCarcinoma
650	0	4	_aCell Hypoxia _xdrug effects
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Proliferation _xdrug effects
650	0	4	_aCheckpoint Kinase 1
650	0	4	_aCheckpoint Kinase 2
650	0	4	_aDrug Screening Assays, Antitumor
650	0	4	_aEnzyme Activation _xdrug effects
650	0	4	_aGene Expression Regulation, Neoplastic _xdrug effects
650	0	4	_aGenome, Viral _xgenetics
650	0	4	_aHerpesvirus 4, Human _xgenetics
650	0	4	_aHumans
650	0	4	_aHypoxia-Inducible Factor 1, alpha Subunit _xantagonists & inhibitors
650	0	4	_aNasopharyngeal Carcinoma
650	0	4	_aNasopharyngeal Neoplasms _xenzymology
650	0	4	_aPoly(ADP-ribose) Polymerases _xmetabolism
650	0	4	_aProtein Kinases _xmetabolism
650	0	4	_aProtein Serine-Threonine Kinases _xmetabolism
650	0	4	_aS Phase _xdrug effects
650	0	4	_aSignal Transduction _xdrug effects
650	0	4	_aTirapazamine
650	0	4	_aTriazines _xpharmacology
650	0	4	_aUp-Regulation _xdrug effects
650	0	4	_aViral Matrix Proteins _xmetabolism
700	1		_aLui, Vivian W Y
700	1		_aHui, Edwin P
700	1		_aNg, Margaret H L
700	1		_aCheng, Suk-Hang
700	1		_aSung, Fion L
700	1		_aTsang, Chi-Man
700	1		_aTsao, Sai-Wah
700	1		_aChan, Anthony Tak-Cheung
773	0		_tInvestigational new drugs _gvol. 29 _gno. 3 _gp. 401-10
856	4	0	_uhttps://doi.org/10.1007/s10637-009-9356-z _zAvailable from publisher's website
999			_c19394783 _d19394783