000 01786 a2200493 4500
005 20250515193552.0
264 0 _c20100225
008 201002s 0 0 eng d
022 _a1525-2191
024 7 _a10.2353/ajpath.2009.081096
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aAmritraj, Asha
245 0 0 _aIncreased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice.
_h[electronic resource]
260 _bThe American journal of pathology
_cDec 2009
300 _a2540-56 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aCathepsin B
_xmetabolism
650 0 4 _aCathepsin D
_xmetabolism
650 0 4 _aCerebellum
_xmetabolism
650 0 4 _aCholesterol
_xmetabolism
650 0 4 _aFluorescent Antibody Technique
650 0 4 _aHippocampus
_xmetabolism
650 0 4 _aImmunoblotting
650 0 4 _aIntracellular Signaling Peptides and Proteins
650 0 4 _aLysosomes
_xenzymology
650 0 4 _aMice
650 0 4 _aMice, Inbred BALB C
650 0 4 _aMice, Knockout
650 0 4 _aMicroscopy, Electron, Transmission
650 0 4 _aNerve Degeneration
_xenzymology
650 0 4 _aNeurons
_xenzymology
650 0 4 _aNiemann-Pick C1 Protein
650 0 4 _aNiemann-Pick Disease, Type C
_xenzymology
650 0 4 _aProteins
_xgenetics
700 1 _aPeake, Kyle
700 1 _aKodam, Anitha
700 1 _aSalio, Chiara
700 1 _aMerighi, Adalberto
700 1 _aVance, Jean E
700 1 _aKar, Satyabrata
773 0 _tThe American journal of pathology
_gvol. 175
_gno. 6
_gp. 2540-56
856 4 0 _uhttps://doi.org/10.2353/ajpath.2009.081096
_zAvailable from publisher's website
999 _c19280969
_d19280969