| 000 | 02802 a2200889 4500 | ||
|---|---|---|---|
| 005 | 20250515192412.0 | ||
| 264 | 0 | _c20091123 | |
| 008 | 200911s 0 0 eng d | ||
| 022 | _a1474-547X | ||
| 024 | 7 |
_a10.1016/S0140-6736(09)61836-5 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aMaguire, Albert M | |
| 245 | 0 | 0 |
_aAge-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. _h[electronic resource] |
| 260 |
_bLancet (London, England) _cNov 2009 |
||
| 300 |
_a1597-605 p. _bdigital |
||
| 500 | _aPublication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAdolescent |
| 650 | 0 | 4 | _aAdult |
| 650 | 0 | 4 | _aAge Factors |
| 650 | 0 | 4 |
_aBlindness _xcongenital |
| 650 | 0 | 4 |
_aCarrier Proteins _xgenetics |
| 650 | 0 | 4 | _aChild |
| 650 | 0 | 4 | _aDark Adaptation |
| 650 | 0 | 4 |
_aDependovirus _xgenetics |
| 650 | 0 | 4 | _aDisease Progression |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aElectroretinography |
| 650 | 0 | 4 |
_aEye Proteins _xgenetics |
| 650 | 0 | 4 | _aFemale |
| 650 | 0 | 4 |
_aGenetic Therapy _xmethods |
| 650 | 0 | 4 |
_aGenetic Vectors _xgenetics |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aInjections |
| 650 | 0 | 4 | _aMale |
| 650 | 0 | 4 |
_aMutation _xgenetics |
| 650 | 0 | 4 | _aNystagmus, Physiologic |
| 650 | 0 | 4 |
_aOptic Atrophy, Hereditary, Leber _xdiagnosis |
| 650 | 0 | 4 | _aSafety |
| 650 | 0 | 4 | _aTreatment Outcome |
| 650 | 0 | 4 | _aVisual Acuity |
| 650 | 0 | 4 | _aYoung Adult |
| 650 | 0 | 4 | _acis-trans-Isomerases |
| 700 | 1 | _aHigh, Katherine A | |
| 700 | 1 | _aAuricchio, Alberto | |
| 700 | 1 | _aWright, J Fraser | |
| 700 | 1 | _aPierce, Eric A | |
| 700 | 1 | _aTesta, Francesco | |
| 700 | 1 | _aMingozzi, Federico | |
| 700 | 1 | _aBennicelli, Jeannette L | |
| 700 | 1 | _aYing, Gui-shuang | |
| 700 | 1 | _aRossi, Settimio | |
| 700 | 1 | _aFulton, Ann | |
| 700 | 1 | _aMarshall, Kathleen A | |
| 700 | 1 | _aBanfi, Sandro | |
| 700 | 1 | _aChung, Daniel C | |
| 700 | 1 | _aMorgan, Jessica I W | |
| 700 | 1 | _aHauck, Bernd | |
| 700 | 1 | _aZelenaia, Olga | |
| 700 | 1 | _aZhu, Xiaosong | |
| 700 | 1 | _aRaffini, Leslie | |
| 700 | 1 | _aCoppieters, Frauke | |
| 700 | 1 | _aDe Baere, Elfride | |
| 700 | 1 | _aShindler, Kenneth S | |
| 700 | 1 | _aVolpe, Nicholas J | |
| 700 | 1 | _aSurace, Enrico M | |
| 700 | 1 | _aAcerra, Carmela | |
| 700 | 1 | _aLyubarsky, Arkady | |
| 700 | 1 | _aRedmond, T Michael | |
| 700 | 1 | _aStone, Edwin | |
| 700 | 1 | _aSun, Junwei | |
| 700 | 1 | _aMcDonnell, Jennifer Wellman | |
| 700 | 1 | _aLeroy, Bart P | |
| 700 | 1 | _aSimonelli, Francesca | |
| 700 | 1 | _aBennett, Jean | |
| 773 | 0 |
_tLancet (London, England) _gvol. 374 _gno. 9701 _gp. 1597-605 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1016/S0140-6736(09)61836-5 _zAvailable from publisher's website |
| 999 |
_c19244548 _d19244548 |
||