000 02384 a2200589 4500
005 20250515190023.0
264 0 _c20110203
008 201102s 0 0 eng d
022 _a1573-0646
024 7 _a10.1007/s10637-009-9324-7
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aRoy Choudhury, Subhasree
245 0 0 _aSynergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification.
_h[electronic resource]
260 _bInvestigational new drugs
_cDec 2010
300 _a812-24 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAngiogenesis Inducing Agents
_xmetabolism
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aBenzenesulfonates
_xpharmacology
650 0 4 _aCaspase 3
_xmetabolism
650 0 4 _aCell Cycle
_xdrug effects
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCell Shape
_xdrug effects
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aCyclin-Dependent Kinase Inhibitor p21
_xmetabolism
650 0 4 _aDown-Regulation
_xdrug effects
650 0 4 _aDrug Synergism
650 0 4 _aFlow Cytometry
650 0 4 _aGene Amplification
_xdrug effects
650 0 4 _aGenistein
_xpharmacology
650 0 4 _aHumans
650 0 4 _aMitochondria
_xdrug effects
650 0 4 _aMyeloid Cell Leukemia Sequence 1 Protein
650 0 4 _aNeuroblastoma
_xdrug therapy
650 0 4 _aNiacinamide
_xanalogs & derivatives
650 0 4 _aPhenylurea Compounds
650 0 4 _aProto-Oncogene Proteins c-bcl-2
_xmetabolism
650 0 4 _aProto-Oncogene Proteins c-myc
_xgenetics
650 0 4 _aPyridines
_xpharmacology
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSorafenib
650 0 4 _aTelomerase
_xmetabolism
650 0 4 _aTreatment Outcome
650 0 4 _aTumor Suppressor Protein p53
_xmetabolism
650 0 4 _aUp-Regulation
_xdrug effects
650 0 4 _abcl-2-Associated X Protein
_xmetabolism
700 1 _aKarmakar, Surajit
700 1 _aBanik, Naren L
700 1 _aRay, Swapan K
773 0 _tInvestigational new drugs
_gvol. 28
_gno. 6
_gp. 812-24
856 4 0 _uhttps://doi.org/10.1007/s10637-009-9324-7
_zAvailable from publisher's website
999 _c19174045
_d19174045