000 01674 a2200457 4500
005 20250515172140.0
264 0 _c20091130
008 200911s 0 0 eng d
022 _a1471-2172
024 7 _a10.1186/1471-2172-10-28
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aShor, Boris
245 0 0 _aA kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.
_h[electronic resource]
260 _bBMC immunology
_cMay 2009
300 _a28 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aB-Lymphocytes
_xdrug effects
650 0 4 _aCarrier Proteins
_xgenetics
650 0 4 _aCatalytic Domain
_xgenetics
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCells, Cultured
650 0 4 _aEmbryonic Development
_xgenetics
650 0 4 _aGene Knock-In Techniques
650 0 4 _aHeterozygote
650 0 4 _aImmune System
_xembryology
650 0 4 _aLymphocyte Activation
_xdrug effects
650 0 4 _aMice
650 0 4 _aMutation
650 0 4 _aPhosphatidylinositol 3-Kinases
_ximmunology
650 0 4 _aPhosphotransferases (Alcohol Group Acceptor)
_xgenetics
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSirolimus
_xpharmacology
650 0 4 _aT-Lymphocytes
_xdrug effects
650 0 4 _aTOR Serine-Threonine Kinases
650 0 4 _aTacrolimus Binding Protein 1A
_xantagonists & inhibitors
700 1 _aCavender, Druie
700 1 _aHarris, Crafford
773 0 _tBMC immunology
_gvol. 10
_gp. 28
856 4 0 _uhttps://doi.org/10.1186/1471-2172-10-28
_zAvailable from publisher's website
999 _c18883627
_d18883627