000 02528 a2200697 4500
005 20250515170535.0
264 0 _c20090921
008 200909s 0 0 eng d
022 _a1528-0020
024 7 _a10.1182/blood-2008-10-186536
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aRemke, Marc
245 0 0 _aHigh-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response.
_h[electronic resource]
260 _bBlood
_cJul 2009
300 _a1053-62 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdolescent
650 0 4 _aAntineoplastic Combined Chemotherapy Protocols
_xtherapeutic use
650 0 4 _aChild
650 0 4 _aChild, Preschool
650 0 4 _aChromosome Deletion
650 0 4 _aChromosomes, Human, Pair 6
_xgenetics
650 0 4 _aComparative Genomic Hybridization
650 0 4 _aCyclin-Dependent Kinase Inhibitor p27
650 0 4 _aFemale
650 0 4 _aGene Dosage
650 0 4 _aHumans
650 0 4 _aIntracellular Signaling Peptides and Proteins
_xgenetics
650 0 4 _aMale
650 0 4 _aMulticenter Studies as Topic
_xstatistics & numerical data
650 0 4 _aNeoplasm Proteins
_xgenetics
650 0 4 _aPhosphatidylinositol 3-Kinases
_xgenetics
650 0 4 _aPrecursor T-Cell Lymphoblastic Leukemia-Lymphoma
_xdrug therapy
650 0 4 _aPrognosis
650 0 4 _aProto-Oncogene Proteins c-akt
_xgenetics
650 0 4 _aReceptor, Notch1
_xgenetics
650 0 4 _aSignal Transduction
_xgenetics
650 0 4 _aTransforming Growth Factor beta
_xgenetics
650 0 4 _aTreatment Outcome
700 1 _aPfister, Stefan
700 1 _aKox, Corinne
700 1 _aToedt, Grischa
700 1 _aBecker, Natalia
700 1 _aBenner, Axel
700 1 _aWerft, Wiebke
700 1 _aBreit, Stephen
700 1 _aLiu, Shuangyou
700 1 _aEngel, Felix
700 1 _aWittmann, Andrea
700 1 _aZimmermann, Martin
700 1 _aStanulla, Martin
700 1 _aSchrappe, Martin
700 1 _aLudwig, Wolf-Dieter
700 1 _aBartram, Claus R
700 1 _aRadlwimmer, Bernhard
700 1 _aMuckenthaler, Martina U
700 1 _aLichter, Peter
700 1 _aKulozik, Andreas E
773 0 _tBlood
_gvol. 114
_gno. 5
_gp. 1053-62
856 4 0 _uhttps://doi.org/10.1182/blood-2008-10-186536
_zAvailable from publisher's website
999 _c18836735
_d18836735