000			01585 a2200409 4500
005			20250515170034.0
264		0	_c20100709
008			201007s 0 0 eng d
022			_a1573-0646
024	7		_a10.1007/s10637-009-9251-7 _2doi
040			_aNLM _beng _cNLM
100	1		_aZhou, Jinming
245	0	0	_aSynthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants. _h[electronic resource]
260			_bInvestigational new drugs _cJun 2010
300			_a291-8 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAndrogen Antagonists _xchemical synthesis
650	0	4	_aAndrogen Receptor Antagonists
650	0	4	_aAntineoplastic Agents, Hormonal _xchemical synthesis
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Proliferation _xdrug effects
650	0	4	_aChalcones _xchemical synthesis
650	0	4	_aDrug Design
650	0	4	_aDrug Resistance, Neoplasm _xgenetics
650	0	4	_aDrug Screening Assays, Antitumor
650	0	4	_aHumans
650	0	4	_aMale
650	0	4	_aMolecular Structure
650	0	4	_aMutation _xdrug effects
650	0	4	_aNorisoprenoids _xchemical synthesis
650	0	4	_aReceptors, Androgen _xgenetics
650	0	4	_aStructure-Activity Relationship
700	1		_aGeng, Guoyan
700	1		_aWu, Jian Hui
773	0		_tInvestigational new drugs _gvol. 28 _gno. 3 _gp. 291-8
856	4	0	_uhttps://doi.org/10.1007/s10637-009-9251-7 _zAvailable from publisher's website
999			_c18821461 _d18821461