000			02065 a2200637 4500
005			20250515155959.0
264		0	_c20090723
008			200907s 0 0 eng d
022			_a1550-7416
024	7		_a10.1208/s12248-009-9083-6 _2doi
040			_aNLM _beng _cNLM
100	1		_aStroh, Mark
245	0	0	_aModel-based decision making in early clinical development: minimizing the impact of a blood pressure adverse event. _h[electronic resource]
260			_bThe AAPS journal _cMar 2009
300			_a99-108 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAdministration, Oral
650	0	4	_aAnimals
650	0	4	_aBiological Availability
650	0	4	_aCircadian Rhythm
650	0	4	_aClinical Trials, Phase I as Topic _xstatistics & numerical data
650	0	4	_aColon
650	0	4	_aComputer Simulation
650	0	4	_aDecision Making
650	0	4	_aDelayed-Action Preparations
650	0	4	_aDogs
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDrug Evaluation, Preclinical
650	0	4	_aDrugs, Investigational _xadministration & dosage
650	0	4	_aGastrointestinal Contents _xchemistry
650	0	4	_aHumans
650	0	4	_aHypertension _xchemically induced
650	0	4	_aIleum
650	0	4	_aIntestinal Absorption
650	0	4	_aJejunum
650	0	4	_aMale
650	0	4	_aModels, Biological
650	0	4	_aRandomized Controlled Trials as Topic _xstatistics & numerical data
650	0	4	_aTablets
650	0	4	_aYoung Adult
700	1		_aAddy, Carol
700	1		_aWu, Yunhui
700	1		_aStoch, S Aubrey
700	1		_aPourkavoos, Nazaneen
700	1		_aGroff, Michelle
700	1		_aXu, Yang
700	1		_aWagner, John
700	1		_aGottesdiener, Keith
700	1		_aShadle, Craig
700	1		_aWang, Hong
700	1		_aManser, Kimberly
700	1		_aWinchell, Gregory A
700	1		_aStone, Julie A
773	0		_tThe AAPS journal _gvol. 11 _gno. 1 _gp. 99-108
856	4	0	_uhttps://doi.org/10.1208/s12248-009-9083-6 _zAvailable from publisher's website
999			_c18643382 _d18643382