000			01705 a2200433 4500
005			20250515151301.0
264		0	_c20090122
008			200901s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm8007689 _2doi
040			_aNLM _beng _cNLM
100	1		_aBolognese, Adele
245	0	0	_aAntitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity. _h[electronic resource]
260			_bJournal of medicinal chemistry _cDec 2008
300			_a8148-57 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aCatalysis
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Proliferation
650	0	4	_aChemistry, Pharmaceutical _xmethods
650	0	4	_aDNA _xchemistry
650	0	4	_aDrug Design
650	0	4	_aDrug Screening Assays, Antitumor
650	0	4	_aEnzyme Inhibitors _xpharmacology
650	0	4	_aHumans
650	0	4	_aInhibitory Concentration 50
650	0	4	_aNeoplasms _xdrug therapy
650	0	4	_aQuinolines _xchemical synthesis
650	0	4	_aStructure-Activity Relationship
650	0	4	_aTopoisomerase II Inhibitors
700	1		_aCorreale, Gaetano
700	1		_aManfra, Michele
700	1		_aEsposito, Anna
700	1		_aNovellino, Ettore
700	1		_aLavecchia, Antonio
773	0		_tJournal of medicinal chemistry _gvol. 51 _gno. 24 _gp. 8148-57
856	4	0	_uhttps://doi.org/10.1021/jm8007689 _zAvailable from publisher's website
999			_c18508111 _d18508111