| 000 | 01626 a2200445 4500 | ||
|---|---|---|---|
| 005 | 20250515145945.0 | ||
| 264 | 0 | _c20090206 | |
| 008 | 200902s 0 0 eng d | ||
| 022 | _a1520-5126 | ||
| 024 | 7 |
_a10.1021/ja8068177 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aLiu, Sijiu | |
| 245 | 0 | 0 |
_aTargeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. _h[electronic resource] |
| 260 |
_bJournal of the American Chemical Society _cDec 2008 |
||
| 300 |
_a17075-84 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 |
_aAmides _xchemistry |
| 650 | 0 | 4 | _aCell Line, Tumor |
| 650 | 0 | 4 | _aCrystallography, X-Ray |
| 650 | 0 | 4 | _aDimerization |
| 650 | 0 | 4 | _aDrug Evaluation, Preclinical |
| 650 | 0 | 4 |
_aEnzyme Activation _xdrug effects |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xchemical synthesis |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aKeto Acids _xchemical synthesis |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 | _aProtein Binding |
| 650 | 0 | 4 |
_aProtein Tyrosine Phosphatase, Non-Receptor Type 1 _xantagonists & inhibitors |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 700 | 1 | _aZeng, Li-Fan | |
| 700 | 1 | _aWu, Li | |
| 700 | 1 | _aYu, Xiao | |
| 700 | 1 | _aXue, Ting | |
| 700 | 1 | _aGunawan, Andrea M | |
| 700 | 1 | _aLong, Ya-Qiu | |
| 700 | 1 | _aZhang, Zhong-Yin | |
| 773 | 0 |
_tJournal of the American Chemical Society _gvol. 130 _gno. 50 _gp. 17075-84 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/ja8068177 _zAvailable from publisher's website |
| 999 |
_c18469583 _d18469583 |
||