| 000 | 02907 a2200949 4500 | ||
|---|---|---|---|
| 005 | 20250515145945.0 | ||
| 264 | 0 | _c20090403 | |
| 008 | 200904s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm801252w _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aMayer, Scott C | |
| 245 | 0 | 0 |
_aDiscovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cDec 2008 |
||
| 300 |
_a7348-51 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 |
_aAlzheimer Disease _xdrug therapy |
| 650 | 0 | 4 |
_aAmyloid Precursor Protein Secretases _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aAmyloid beta-Peptides _xmetabolism |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aCrystallography, X-Ray |
| 650 | 0 | 4 | _aDisease Models, Animal |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aDrug Discovery |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xchemical synthesis |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 | _aMice, Transgenic |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMolecular Conformation |
| 650 | 0 | 4 |
_aReceptor, Notch1 _xmetabolism |
| 650 | 0 | 4 | _aStereoisomerism |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aSulfonamides _xchemical synthesis |
| 650 | 0 | 4 |
_aThiophenes _xchemical synthesis |
| 700 | 1 | _aKreft, Anthony F | |
| 700 | 1 | _aHarrison, Boyd | |
| 700 | 1 | _aAbou-Gharbia, Magid | |
| 700 | 1 | _aAntane, Madelene | |
| 700 | 1 | _aAschmies, Suzan | |
| 700 | 1 | _aAtchison, Kevin | |
| 700 | 1 | _aChlenov, Michael | |
| 700 | 1 | _aCole, Derek C | |
| 700 | 1 | _aComery, Thomas | |
| 700 | 1 | _aDiamantidis, George | |
| 700 | 1 | _aEllingboe, John | |
| 700 | 1 | _aFan, Kristi | |
| 700 | 1 | _aGalante, Rocco | |
| 700 | 1 | _aGonzales, Cathleen | |
| 700 | 1 | _aHo, Douglas M | |
| 700 | 1 | _aHoke, Molly E | |
| 700 | 1 | _aHu, Yun | |
| 700 | 1 | _aHuryn, Donna | |
| 700 | 1 | _aJain, Uday | |
| 700 | 1 | _aJin, Mei | |
| 700 | 1 | _aKremer, Kenneth | |
| 700 | 1 | _aKubrak, Dennis | |
| 700 | 1 | _aLin, Melissa | |
| 700 | 1 | _aLu, Peimin | |
| 700 | 1 | _aMagolda, Ron | |
| 700 | 1 | _aMartone, Robert | |
| 700 | 1 | _aMoore, William | |
| 700 | 1 | _aOganesian, Aram | |
| 700 | 1 | _aPangalos, Menelas N | |
| 700 | 1 | _aPorte, Alex | |
| 700 | 1 | _aReinhart, Peter | |
| 700 | 1 | _aResnick, Lynn | |
| 700 | 1 | _aRiddell, David R | |
| 700 | 1 | _aSonnenberg-Reines, June | |
| 700 | 1 | _aStock, Joseph R | |
| 700 | 1 | _aSun, Shaiu-Ching | |
| 700 | 1 | _aWagner, Erik | |
| 700 | 1 | _aWang, Ting | |
| 700 | 1 | _aWoller, Kevin | |
| 700 | 1 | _aXu, Zheng | |
| 700 | 1 | _aZaleska, Margaret M | |
| 700 | 1 | _aZeldis, Joseph | |
| 700 | 1 | _aZhang, Minsheng | |
| 700 | 1 | _aZhou, Hua | |
| 700 | 1 | _aJacobsen, J Steven | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 51 _gno. 23 _gp. 7348-51 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm801252w _zAvailable from publisher's website |
| 999 |
_c18469580 _d18469580 |
||